Chronic schistosomiasis infection has long been known to be associated with bladder cancer and colorectal cancer. Careful evaluation of this connection has not been done. The purpose of the present study was to evaluate the histopathologic and genetic changes seen in chronic schistosomiasis patients with colorectal cancer as compared to people who had colorectal cancer without schistosomiasis.
Schistosoma mansoni is the parasitic organism commonly seen in Egypt. Schistosoma japonicum is the organism most common in Asia.
Patients with colorectal cancer and schistosomiasis tended to have mucinous adenocarcinoma. Schistosomiasis is commonly seen with bladder cancer. In as much as 20% of such tumors, parasite eggs or masses are even seen within the tumors.
p53 overactivity in cancers with schistosomiasis is seen in as many as 90% of such cases. This is suggestive that schistosomiasis alters a protein which is causative of the colorectal cancer.
An earlier age of onset of colorectal cancer is seen when there is coincidental schistosomiasis.
CONCLUSION: Schistosomal colitis is associated with early onset of multicentric colorectal cancer and increased incidence of mucinous adenocarcinoma tumors that present at an advanced stage. There is the possibility that increased p53 activation could be the inciting event for colorectal cancer.
NOTE: Researcher, Hilda Clark, has written on the relationship between cancer and parasite infection in “The Cure For All Cancers.” Li, WC reported on a case of colon carcinoma with Schistosoma japonicum within the cancer and in associated lymph nodes (Summary 231). p53 is a protein commonly seen in association with cancer. Read about a sigmoid colon cancer associated with schistosomes.
Read about organic parasite control for animals.
ASK YOUR DOCTOR FOR: A fecal sample to examine for parasites.
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PMID: 16786317.
Summary #224.
