Apigenin, Chrysin, and Luteolin are Proteasome Inhibitors in Tumor Cells.

Posted on September 5, 2009 by Dr. Gary Pack

The proteasomes of cells regulate apoptosis (a natural form of cell death for abnormal cells.) Proteasome activity is increased in cancer cells. Proteasome inhibition arrests cell growth and induces apoptosis in abnormal cells. Proteasome inhibition is seen as a useful therapy against cancers such as multiple myeloma and non-Hodgkin’s lymphoma. Because of the toxicity of […]

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Conditions: Apoptosis, Cell death, Colon cancer, Leukemia, Liver cancer, Lung cancer, Multiple myeloma, Non-Hodgkin's lymphoma

Supplements: Bioflavonoids, Chrysin, EGCG (epigallocatechin gallate)

Foods: Coffee, Tea (Camellia sinensis), Wine

Miscellaneous: Anti-inflammatory, Anticancer, Antioxidant, Antiviral, Apigenin, Flavonoids, Luteolin, Proteasome, Proteasome inhibitors

Baicalin is a CNS Prolyl Oligopeptidase Inhibitor.

Posted on November 25, 2008 by Dr. Gary Pack

A chemical called protease prolyl oligopeptidase (POP) is associated with schizophrenia, bipolar affective disorder, and, possibly, Alzheimer’s disease. In a previous study of Chinese herbs, baicalin, a flavonoid, was found to inhibit POP. Baicalin is found in Scutellaria baicalensis (skullcap) root. The authors studied whether baicalin and it’s derivative, baicalein, would cross the intestinal barrier […]

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Conditions: Alzheimer's disease, Angiogenesis, Bipolar depression, Cancer, Neuropsychiatric disease, Schizophrenia

Supplements: Bioflavonoids, Coptis (Coptis chinensis), Quercetin, Skullcap (Scutellaria baicalensis)

Miscellaneous: Berberine, Flavonoids, Luteolin, Propyl oligopeptidase

Dietary Flavonoids and the Anticancer Effects of Bortezomib.

Posted on November 16, 2008 by Dr. Gary Pack

Bortezomib is a pharmaceutical proteasome inhibitor which is a strong treatment for multiple myeloma. Bortezomib induces apoptosis in leukemia cells in the laboratory. Yet, it is not effective in human studies of chronic lymphocytic leukemia (CLL). (Proteasome inhibition in the bone marrow is 1/2 that in the blood.) We eat about 23 mg. of flavonoids […]

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Conditions: Apoptosis, Chronic lymphocytic leukemia, Leukemia, Multiple myeloma

Supplements: Bioflavonoids, N-acetylcysteine (NAC), Quercetin

Foods: Fruits, Onions, Vegetables

Miscellaneous: Apigenin, Flavonoids, Luteolin, Myricetin, Proteasome inhibitors

Dietary Flavonoids and Leukemia Cells.

Posted on May 25, 2007 by Dr. Gary Pack

Annually about 10 million people develop cancer and about 6.2 million people die of cancer worldwide. Cancer cells have altered chemical pathways that lead to rapid growth and division of cells and reduced apoptosis (cell suicide). Overriding these functions can be therapeutic in patients with cancer and the proteasome pathway plays a role in these […]

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