Arginase Inhibitors for Endothelial Dysfunction.

Posted on June 9, 2015 by Dr. Gary Pack

Endothelial dysfunction plays a major role in ischemic cardiovascular disease, hypertension and cerebrovascular disease. Endothelium (inner lining of blood vessels) produces chemicals which result in relaxation of blood vessel muscles so the blood vessels can dilate. Also, produced are chemicals which cause the blood vessels to constrict. An imbalance in this dilation and constriction can […]

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Conditions: Cardiovascular disease, Endothelial dysfunction, Hypertension, Vasoconstriction

Supplements: Amino acids, Arginine, Norvaline, Ornithine

Miscellaneous: Ammonia, Arginase, Arginase inhibitors, Enzymes, Nitric oxide (NO), Nitric oxide synthetase, Nitrogen oxide, Urea

Tetrahydrobiopterin (BH4,) Endothelial Function and Ageing.

Posted on October 13, 2012 by Dr. Gary Pack

With advancing age, there is a reduction in the ability of arteries to dilate in humans and in rodents. This is related to a reduction in nitric oxide (NO) in the inner lining of arteries (the endothelium.) This is partly due to reduced production of an enzyme called NO synthase (NOS) and partly due to […]

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Conditions: Aging

Supplements: Antioxidants, Folic acid (folate), Ornithine

Miscellaneous: Nitric oxide (NO), Sepiapterin, Tetrahydrobiopterin

Arginine in Asthma.

Posted on August 16, 2012 by Dr. Gary Pack

L-arginine is metabolized by the arginase enzyme and by the nitric oxide synthase (NOS) enzyme. Abnormalities in the arginine and the arginase and nitric oxide synthase pathways can lead to airway hyperresponsiveness (AHR,) as seen in asthma. Exhaled levels of nitric oxide (NO) are elevated in asthma. Arginine therapy has been shown to be beneficial […]

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Conditions: Airway hyperresponsiveness, Asthma

Supplements: Arginine, Citrulline, Ornithine

Miscellaneous: Nitric oxide (NO), Nitric oxide synthetase, Peroxynitrite

Arginase: a Key Enzyme in Allergic Asthma.

Posted on August 16, 2010 by Dr. Gary Pack

Allergic asthma causes obstruction of bronchi and airway hyperresponiveness (AHR.) Eventually, there are inflammation and remodeling of the airways. The enzyme, arginase, may play a part in this. Reduced availability of arginine may be involved, resulting in problems with bronchoconstriction from reduced levels of nitric oxide (NO.) Arginine deficiency results in increased levels of peroxynitrite, […]

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Conditions: Asthma, Bronchoconstriction, Inflammation

Supplements: Arginine, Citrulline, Ornithine, Rhubarb (Rheum rhabarbarum)

Miscellaneous: Arginase, Nitric oxide (NO), Nitric oxide synthetase, Peroxynitrite, Polyamines, Prolines, Putrescine, Spermidine, Spermine, Urea

How to Elevate Night Time Growth Hormone Release.

Posted on March 29, 2007 by Dr. Gary Pack

Growth hormone (GH) is the major hormone in the human body that maintains healthy muscle status (anabolic hormones such as GH build up living cells). In adulthood, GH levels gradually decline in humans. The author of this article proposes a new, patented technique for increasing night-time GH release by using 25-100 mg. l-ornithine and 500 […]

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Conditions: Aging, Growth hormone deficiency, Stress

Supplements: Acetylcarnitine, Arginine, Ornithine

Miscellaneous: ACTH (growth hormone), Hypothalamic-pituitary-adrenal (HPA) axis, Hypothalamus, Pituitary gland

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