Multiple sclerosis (MS) is an inflammatory autoimmune disease of the central nervous system (CNS.)Probiotics, which are immunomodulatory, are believed to be therapeutic in MS.Specific probiotics can reduce immune responses and balance pro-inflammatory and anti-inflammatory activities.Intestinal bacteria and gut barrier health are important in development of inflammatory disease.
Lactobacillus (L.) paracasei DSM 13434, L. plantarum DSM 15312 and L. plantarum DSM 15313 were studied in the present research project.The individual species were unable to stop a model of MS in mice, experimental allergic encephalomyelitis (EAE) when used alone.A combination of the probiotics was able, in a previous study, to prevent or delay the onset of EAE.
The combination of the above three probiotics was capable, in this study, of preventing EAE in mice.This combination has potential for treatment of MS in humans.The probiotics work synergistically in reducing T cell-mediated CNS inflammation.It was shown that probiotics produce IL-10 in T cells, which reduces inflammation.The peripheral blood of treated mice was shown to have increased IL-10.
Blood from the mice treated with probiotics was transferred to mice which were later induced to develop EAE.The mice which had been pretreated with the transferred blood had suppression of the development of EAE.
CONCLUSION: Treatment with a combination of three probiotics (L. paracasei DSM 13434, L. plantarum DSM 15312 and L. plantarum DSM 15313) prevents inflammatory EAE of the nervous system in mice and increases IL-10 in the blood.
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PMID: 20126401.
Summary #502.
