Serotonin (5-hydroxytryptamine or 5-HT) agonists mimic and enhance the effect of 5-HT. A 5-HT agonist produces a “high” and a craving response in some people with impulse disorders and some substance abuse disorders. The present study was done to evaluate 5-HT metabolism in gamblers.
After a dose of a 5-HT agonist, the subjects were tested for feelings of “high” and cravings. Serum prolactin and cortisol levels were compared between non-gamblers and placebo-dosed controls. Twenty-six normal controls and 26 gamblers were tested.
Pathologic gamblers had showed significantly increased blood levels of prolactin 180 minutes and 210 minutes after dosing with a 5-HT agonist. Also, the gamblers reported greater senses of “high” with the 5-HT agonists than did the normal controls.
CONCLUSION: The author’s concluded that the “high” of gamblers could be related to a problem with serotonin regulation. Cortisol dysregulation was not reported in the abstract.
NOTE: This summary is based on the author’s abstract, only. The full article is not available at this time.
Increased 5-HT levels are associated with increased prolactin levels, which are associated with increased risk of certain cancers.
Serotonin agonists include the following, which increase prolactin: tryptophan, 5-OH tryptophan, certain anti-psychotic drugs, and untreated Parkinsonism. Dopamine activity is increased by the following which reduce prolactin activity: dopamine agonists such as tyrosine, vitex and anti-Parkinsonism drugs. 5-lipoxygenase inhibitors, such as Boswellia serrata (Boswellin,) reduce prolactin levels.
To read the author’s abstract of the article click on the link to the author’s title of the article above.
PMID: 17146409.
Summary #285.
