Proton Pump Inhibitors, Melanoma and Tumor Acidity.

Posted on November 24, 2009 by Dr. Gary Pack

Metastatic melanoma is known to have poor survival rates. We are learning that a major change in cancer cells is intracellular alkalinization and extracellular acidification, early. The acid environment drives proliferation, invasion and metastasis. The alkaline interior of the cell prevents apoptosis of cancer cells. A recent approach to cancer treatment is the use of […]

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Conditions: Acidosis (acidity), Alkalosis (alkalinity), Apoptosis, Cancer, Chemotherapy, Melanoma, Multidrug resistance (MDR)

Supplements: Cinnamate, Quercetin, Resveratrol

Miscellaneous: Na/K, Proton pump inhibitors

Proton Transport Inhibitors as Anticancer Drugs.

Posted on September 19, 2009 by Dr. Gary Pack

Reversal of the normal movements of protons across cell walls seems to underlie all cancer development. The reversal of the normal pH balance across the cancer cell walls results in an intracellular alkalosis with high pH and an extracellular acidosis with low pH. The reversal of the proton gradient across the cell wall, seen only […]

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Conditions: Acidosis (acidity), Alkalosis (alkalinity), Angiogenesis, Apoptosis, Cancer, Chemotherapy, Melanoma, Multidrug resistance (MDR), Neuroblastoma cancer, Spontaneous remission

Supplements: Quercetin, Resveratrol

Miscellaneous: Proton pump inhibitors, VEGF (vascular endothelial growth factor)

Marijuana for Nausea and Vomiting from Chemotherapy..

Posted on July 25, 2009 by Dr. Gary Pack

Oral delta-9-tetrahydrocannabinol (THC) and smoked marijuana (Cannabis sativa) are used to treat chemotherapy-induced nausea and vomiting (CINV). CINV results from chemotherapy with the release of the following neurotransmitters: dopamine, histamine, acetylcholine and serotonin. Nausea results in appetite loss and poor nutrition. Vomiting causes tooth problems, malnutrition and weight loss. There are over 60 cannabinoids besides […]

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Conditions: Chemotherapy, Nausea, Vomiting

Supplements: Histamine

Miscellaneous: Acetylcholine, Dopamine, Marijuana (Cannabis sativa), Serotonin, Tetrahydrocannabinol

Spontaneous Regression of Liver Cancer.

Posted on June 6, 2009 by Dr. Gary Pack

Four men with hepatocellular carcinoma (HCC) are reported who had a spontaneous regression of their tumors.They all had a history of hepatitis C viral infections and liver cirrhosis, and showed a rapid increase of blood alpha-fetoprotein (AFP) just before cancer remission. With remission, all of their AFP levels in the blood rapidly returned to normal. […]

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Lactoferrin Augments Cancer Chemotherapy.

Posted on February 15, 2008 by Dr. Gary Pack

Body secretions contain lactoferrin (Lf,) an iron-containing protein which is a natural defense to tissues commonly exposed to bacteria. Lf has been shown to have the following functions: 1. Regulation of intestinal iron absorption. 2. Promotion of intestinal cell growth. 3. Protection from bacterial infections. 4. Promotion of white cell growth. 5. Control of the […]

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Conditions: Anemia, Arthritis, Asthma, Bladder cancer, Chemotherapy, Colon cancer, Esophageal cancer, Inflammation, Inflammatory bowel disease, Lung cancer, Neurodegeneration, Tongue cancer

Supplements: Lactoferrin

Melatonin as Related to Cancer.

Posted on January 9, 2008 by Dr. Gary Pack

Melatonin is a natural neurohormone found in the human body. It is produced in the pineal gland, primarily. It can be produced in the gut, retina, skin and white blood cells. One function of melatonin is to help maintain sleep-wake cycles. Melatonin is found in all living organisms, such as green algae, bacteria, fungi, plants, […]

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Lactoferrin and Stem Cell Transplants.

Posted on September 13, 2007 by Dr. Gary Pack

Lactoferrin is a glycoprotein of the innate immune system and its receptors are found in many tissues of the body. Lactoferrin and its derivatives have the following properties: 1. Broad spectrum anti-microbial activity. 2. Anti-tumor activity with apoptosis in cancer cells. 3. Regulation of cell growth and differentiation. 4. Modulation of inflammatory, humoral and cellular […]

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pH Dynamics in Cancer.

Posted on August 16, 2007 by Dr. Gary Pack

There are about 100 different diseases which can be called cancer, but there are a few common mechanisms behind the transformation of normal cells into cancer cells. There is evidence that behind cancer development is an underlying severe alkalinization of the interior of the cells. An abnormal handling of the hydrogen ions by the cells […]

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Conditions: Acidosis (acidity), Alkalosis (alkalinity), Angiogenesis, Apoptosis, Cancer, Chemotherapy, Hepatocellular cancer, Leukemia, Multidrug resistance (MDR), Spontaneous remission

Supplements: Acetic acid, HCl (hydrochloric acid), pH paper, Quercetin

Foods: Vinegar (acetic acid)

Miscellaneous: Ammonium chloride, DNA, Hydrogen, Lactic dehydrogenase (LDH), pH, Proton pump inhibitors, Transporter

Immunomodulatory Effects of Baptisia and Echinacea.

Posted on August 2, 2007 by Dr. Gary Pack

The authors studied the influence of arabinogalactan-proteins (AGPs) on the white blood cells of mice. AGPs are found in the roots of Baptisia tinctoria, Echinacea purpurea and Echinacea pallida. The ability of AGPs to increase lymphocytes, increase IGM production, increase nitrite production and increase IL-6 production in mice was tested in the lab. The high […]

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Conditions: Chemotherapy

Supplements: Arabinogalactans, Baptisia (Baptisia tinctorum), Echinacea (Echinacea pallida), Echinacea (Echinacea purpurea)

Miscellaneous: B cell lymphocytes, IL-6, Immunoglobulins

Silibinin and Hepatocellular Carcinoma.

Posted on March 6, 2007 by Dr. Gary Pack

Hepatocellular carcinoma (HCC) of the liver, which has no current effective treatment, is the world’s second most common recurrent cancer, with one million people dying of HCC annually worldwide. The treatment is poor at present because of drug resistance and the severe toxicity of the drugs used for chemotherapy. HCC cells are especially resistant to […]

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Conditions: Apoptosis, Bladder cancer, Breast cancer, Cancer, Chemotherapy, Colon cancer, Fungal infection, Hepatitis, Hepatitis B, Hepatitis C, Hepatocellular cancer, Lung cancer, Multidrug resistance (MDR), Prostate cancer, Skin cancer

Supplements: Milk thistle (Silybum marianum), Silibinin, Silymarin

Miscellaneous: Aflatoxin, Aspergillus mold, Liver

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