Homocysteine as a Marker of Neurodegenerative Disease.

Posted on July 6, 2015 by Dr. Gary Pack

Homocysteine (Hcy) is a chemical found in the blood; high Hcy levels (HHcy) are commonly associated with neurodegenerative disease. HHcy is often seen in elderly people and is associated with increased risk of Alzheimer’s disease, vascular dementia, cognitive impairment, and stroke. Also, HHcy is associated with vitamin B deficiency (folate, B12, B6) and is a […]

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Conditions: Alzheimer's disease, Brain atrophy, Cognitive impairment, Hyperhomcysteinemia, Neurodegenerative disease, Neurotoxicity, Stroke, Vascular disease

Supplements: Folic acid (folate), Vitamin B, Vitamin B-12, Vitamin B-6 (pyridoxine)

Miscellaneous: Biomarker, Homocysteine

Anti-Anxiety Effect of Coriander.

Posted on May 26, 2015 by Dr. Gary Pack

The aim of this study was to evaluate the anti-anxiety activity of an extract of coriander in animals as compared to diazepam (Valium). Coriander (Coriandrum sativum) is an herbal remedy which has many uses. It is a spice used in many parts of the world as well as a medicine in the Indian medicine tradition […]

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Conditions: Alzheimer's disease, Anxiety, Fear, Hypercholesterolemia, Indigestion, Lung disease, Neurodegenerative disease

Supplements: Coriander (Coriandrum sativa)

Miscellaneous: Acetylcholinesterase, Acetylcholinesterase (ACE) inhibitior, Anti-anxiety, Ayurvedic medicine, Memory, Valium (diazepam)

Polyphenols and Aortic Cardiovascular Disease.

Posted on May 14, 2015 by Dr. Gary Pack

Polyphenols are found in fruits and vegetables and, significantly, a diet rich in polyphenols may reduce the risk of cardiovascular disease. The distribution of polyphenols in human body tissues was unknown before this study and the authors developed a new antibody technique to study polyphenols in living tissue. This makes it possible to study the […]

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Conditions: Arteriosclerosis (atherosclerosis), Cancer, Cardiovascular disease, Metastases, Neurodegenerative disease, Oxidative stress

Supplements: Antioxidants, Catechins, Green tea, Isoflavonoids, Quercetin, Stone breaker (Phyllanthus niruri), Vitamin C (ascorbic acid)

Foods: Beverages, Chocolate, Fruits, Green tea (Camellia sinensis), Matcha green tea, Onions, Vegetables, Wine

Miscellaneous: Anti-inflammatory, Aorta, Foam cells, Macrophage, Polyphenols

Catechins in Ashwagandha.

Posted on April 28, 2015 by Dr. Gary Pack

Ashwagandha (Withania somnifera) has long been used as a traditional medicinal plant in India for many problems. It is called Indian ginseng. Recent studies have shown that it is beneficial to the immune system and has antitumor effects. It is useful for arthritis, stress, and problems of aging. Abundant evidence indicates that free radical production […]

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Non-Cancer Uses for Histone Deacetylase Inhibitors.

Posted on April 27, 2015 by Dr. Gary Pack

The DNA genetic material of cells changes configuration when undergoing reproduction and repair. As a result, the chromatin* fibers of DNA become more open to chemical changes. These changes occur due to methylation (addition of a methyl group) of the DNA and acetylation (change of an acetyl group). The amount of acetylation is due to […]

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Green Tea and Climate Change.

Posted on April 21, 2015 by Dr. Gary Pack

Most of the world’s tea is grown in China where much of the land is in high-risk areas for climate change. The cycle of drought followed by monsoons has become a pattern over the past 40 years. The study took place in an evergreen broadleaf forest where the tea grown is of premium quality, and […]

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Conditions: Age-related bone disease, Cancer, Cardiovascular disease, Climate change, Inflammation, Metabolic syndrome, Neurodegenerative disease, Oxidative stress, Skin aging

Supplements: Antioxidants, Catechins, EGCG (epigallocatechin gallate)

Foods: Green tea (Camellia sinensis)

Miscellaneous: Catechins, China, Climate change, Income, Methylxanthine, Polyphenols

5-Lipoxygenase and Amyloid Formation in Alzheimer’s Disease.

Posted on April 20, 2015 by Dr. Gary Pack

Alzheimer’s disease (AD) is a neurodegenerative disease of the brain. In AD a tangled protein called amyloid is formed in brain cells and regulated by 5-lipoxygenase (5-LO) enzymes, which are inflammatory. This 5-LO enzyme pathway is involved in several inflammatory processes, such as arteriosclerosis, cardiovascular disease, and aging of the brain. Patients with AD have […]

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Conditions: Aging, Alzheimer's disease, Arteriosclerosis (atherosclerosis), Cardiovascular disease, Inflammation, Neurodegenerative disease

Supplements: Boswellia (Boswellia serrata), Curcumin, Milk thistle (Silybum marianum), Silymarin, Turmeric (Curcuma longa)

Miscellaneous: 5-lipoxygenase, 5-lipoxygenase inhibitors, Amyloid, Beta-amyloid, Central nervous system

Cloves and Alzheimer’s Disease.

Posted on April 20, 2015 by Dr. Gary Pack

In Alzheimer’s disease (AD), reduced brain acetylcholine (Ach) neurotransmitter is seen. Cognition and behavior changes in AD are reported to be related to these reduced levels. The hypothesis is that inhibition of the enzymes that break down Ach is beneficial in treating neurodegenerative disorders. For example, cetylcholinesterase (AChE) enzyme activity breaks down acetylcholine neurotransmitter in […]

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Conditions: Alzheimer's disease, Cognitive impairment, Neurobehavioral disorder, Neurodegenerative disease

Supplements: Cloves (Syzygium aromaticum), Huperzine A

Miscellaneous: Acetylcholine, Acetylcholinesterase, Acetylcholinesterase (ACE) inhibitior, Ayurvedic medicine, Eugenol, Iranian traditional medicine, Neurobehavior, Neurotransmitters

Aluminum and Neurodegenerative Disease.

Posted on April 20, 2015 by Dr. Gary Pack

Although aluminum (Al) is the most common mineral in the Earth’s crust, it seems to have no useful function in plants or animals. Al was unknown in our environment until extraction for industrial uses began in the 1820’s. Humans get Al internally mostly from food. Now it is used in “food processing, manufacturing, medicines, cosmetics, […]

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Iron Metabolism in Neurodegenerative Diseases.

Posted on April 22, 2014 by Dr. Gary Pack

Poor regulation of iron metabolism is seen in some patients with neurodegenerative diseases, such as Parkinson’s disease (PD), Alzheimer’s disease (AD), and amyotrophic lateral sclerosis (ALS). Iron transport in and out of brain cells helps maintain cellular balance. Imbalance in iron levels produces neurotoxins, reactive oxygen species and oxidative stress. Iron accumulation in the cells […]

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Conditions: Alzheimer's disease, Amyotrophic lateral sclerosis, Apoptosis, Friedreich's Ataxia, Iron overload, Neurodegenerative disease, Oxidation, Oxidative stress, Parkinson's disease, Thalassemia

Supplements: Iron chelator, Lactoferrin

Miscellaneous: Glial cells, Iron chelator, Reactive oxygen species

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