Treatment of Cutaneous T-Cell Lymphoma.

Posted on October 13, 2012 by Dr. Gary Pack

Cutaneous T-Cell Lymphomas (CTCLs) include a group of non-Hodgkin’s lymphomas, including mycosis fungoides and Sezary syndrome. A number of treatments are available; but, patients often become resistant to standard therapy. New treatments are needed and are reviewed by the authors. Mycosis fungoides is slow growing and has a good prognosis. Sezary syndrome is more aggressive […]

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Conditions: Chemotherapy, Cutaneous T-cell lymphoma, Mycosis fungoides, Non-Hodgkin's lymphoma, Sezary syndrome, Ultraviolet light

Supplements: Butyrate

Miscellaneous: Deacetylation enzymes, Histone deacetylase inhibitors, Stem cells (progenitor), UV (ultraviolet) light

Carboxylic Acid Derivatives as Histone Deacetylase Inhibitors.

Posted on July 18, 2009 by Dr. Gary Pack

A group of 33 carboxylic acid related chemicals were tested for histone deacetylase (HDAC) inhibitor activity to learn which molecular structures are most active. Histone acetylation and deacetylation are important for gene expression. Deacetylation causes condensation of chromatin of the DNA. With condensation, information from the DNA is more difficult to access. Inhibition of deacetylation […]

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Conditions: Cancer, Inflammation, Neurodegeneration

Supplements: Butyrate, Caffeic acid, Chlorogenic acid, Curcumin

Miscellaneous: Acetylation, Deacetylation enzymes, Epigenetics, Histone deacetylase inhibitors, Polyphenols, Valproic acid (Valproate)

Regulation of Genes by Botanicals.

Posted on May 6, 2007 by Dr. Gary Pack

The ability of cells to control the expression of genes is important for cell survival. Nutrients can alter the gene expression that controls levels of bioactive proteins. Herbs alter gene activity in various ways. Gene transcription, the most important, is the initial step in gene expression. The pregnane X receptor (PXR receptor) is the target […]

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Conditions: Cancer, Gene expression

Supplements: EGCG (epigallocatechin gallate), Hyperforin, Isoflavones, Phytoestrogens, Quercetin, Red clover (Trifolium pretense), Resveratrol, St. John's Wort (Hypericin perforatum)

Foods: Grapes, Soy, Wine

Miscellaneous: Bile acids, Deacetylation enzymes, DNA, Endrocrine disruptors, Estrogen, Flavones, Gene transcription, Polyphenols, Proteasome, RNA, Sirtuins

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