Choline, Methyl Donors, and Epigenetics.

Posted on July 14, 2017 by Dr. Gary Pack

The DNA* of nearly every cell of a human body is normally identical and defines the body’s genetics. The identical DNA is able to form the wide variety of tissues of the body by epigenetics. DNA expression is altered by epigenetics to create different tissues, such as heart muscle and liver cells. This can happen […]

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Conditions: Cancer, Diabetes, Fetus, Obesity, Pregnancy

Supplements: Betaine (trimethylglycine) (TMG), Choline, DNA, DNA/RNA, Methionine, Methylfolate ', Phosphatidylcholine, S-adenosylmethionine (SAMe)

Foods: Eggs, Meat

Miscellaneous: Environment, Epigenetics, Histone modification, Methyl, Methyl donor

SAM (SAMe) and Alcoholic Liver Disease.

Posted on March 14, 2017 by Dr. Gary Pack

Alcoholism is a major cause of liver disease and death in the U.S. Among adults, 52% are “regular drinkers”. Alcoholic liver disease (ALD) includes fatty liver, alcoholic hepatitis and alcoholic cirrhosis. Epigenetic* mechanisms have been shown to play a role in ALD, and this review focuses on abnormal nutrient availability causing histone modifications which may […]

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Flavonoids and Cancer.

Posted on December 15, 2016 by Dr. Gary Pack

Flavonoids are part of the healthy polyphenol family of chemicals which occur in plants. There are more than 4000 different flavonoids, mostly in fruits, vegetables and seeds. We eat about 1,000 mg. of flavonoids per day. Numerous health benefits have been discovered in flavonoids, including anticancer, anti-mutagenic (prevention of mutations), antioxidant, and antiviral properties. Flavonoids […]

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Conditions: Apoptosis, Breast cancer, Cancer, Oxidation, Prostate cancer, Viral infection

Supplements: Bioflavonoids, Citrus bioflavonoids, Daidzein, Genistein, Glycitein, Isoflavones, Milk thistle (Silybum marianum), Phytoestrogens, Silibinin

Foods: Brussel's sprouts, Fruits, Green tea (Camellia sinensis), Plants, Seeds, Vegetables

Miscellaneous: Anti-aromatase, Anticancer, Antimutagenic, Antioxidant, Antiviral, Aromatase, Cyclooxygenase, DNA, Enzymes, Epigenetics, Estrogen receptors, Flavonoids, Kinase, Mutation, Phosphodiesterase, Phospholipase, RNA

Colon Bacteria, Diet and Colon Cancer Risk.

Posted on August 14, 2015 by Dr. Gary Pack

Most colon cancers are believed to be due to diet. The authors of this study speculate that products of the metabolism of food by the colon microbiome determine the risk of colon cancer. Dietary patterns can change cancer risk, and diets rich in fresh fruit, vegetables, fiber, antioxidants, calcium, and vitamin D reduce the risk […]

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Conditions: Cancer, Colon cancer

Supplements: Biotin, Butyrate, Calcium, Folic acid (folate), FOS (fructooligosaccharide), Iron, Lactobacillus plantarum, Lactobacillus rhamnoses, Prebiotics, Zinc

Foods: Maize

Miscellaneous: African Americans, Africans, Caucasians, Diet, Epigenetics, Epithelium, Fats, Microbiota, Nitrogen

Bee Pollen Allergy.

Posted on July 14, 2015 by Dr. Gary Pack

Bee pollen is sold as a health supplement made up of granules of pollen from various blooming plants and honey produced by the honey bees. Allergic reactions to pollen have rarely been reported in the medical literature. This study is about a severe allergic reaction to bee pollen containing pollen from chrysanthemum, dandelion, and ragweed […]

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Conditions: Asthma, Breastfeeding, Caesarian delivery, Cardiovascular disease, Prenatal

Supplements: Probiotics

Miscellaneous: Commensal bacteria, Environment, Epigenetics, Gut, Immune system, Microbiome, Microbiota, Wind

Bisphenol A and Breast Cancer.

Posted on July 6, 2015 by Dr. Gary Pack

Diethylstilbesterol (DES) and Bisphenol A (BPA) are endocrine disrupting chemicals (EDCs) with estrogen and other hormone activity, which alters the normal development of tissues due to hormonal imbalances. The changes are not just the result of temporary exposure to estrogenic effects. Perhaps ten million women have been treated over the years with DES, which is […]

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Conditions: Bisphenol toxicity, Breast cancer, Fetus, Methylation, Pregnancy

Miscellaneous: Bisphenol, Carcinogens, Diethylstilbesterol, DNA, Endocrine disruptors, Epigenetics, Estrogen, Histone deacetylation, Methylation, Uterus

ER-Negative Breast Cancer, Green Tea, and Broccoli.

Posted on June 16, 2015 by Dr. Gary Pack

Breast cancer therapy with tamoxifen is beneficial in women who have tumors which have estrogen receptors (ER-positive). They are treated with either “selective estrogen receptor modulators”, such as tamoxifen, or with aromatase inhibitors. ER-negative tumors do not respond well to those treatments and account for 25-30% of breast tumors. The ER-negative tumors are not the […]

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Conditions: Breast cancer, Hypermethylation

Supplements: EGCG (epigallocatechin gallate), Green tea, Green tea extract, S-adenosylmethionine (SAMe), Sulforaphane

Foods: Broccoli, Green tea (Camellia sinensis)

Miscellaneous: DNA, Epigenetics, Homocysteine, Tamoxifen

Diet-Dependent Acid Load.

Posted on June 9, 2015 by Dr. Gary Pack

Genes and epigenetic mechanisms, by which we function today, were laid down between 50,000 and 100,000 years ago in Africa. Evolution has continued to this today. However, our basic lifestyles (diet, exercise) have changed drastically over time, and basic food patterns are considerably different today. With human world-wide migration, diets changed from the original patterns, […]

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Conditions: "Diseases of Civilization", Degenerative disease, Inflammatory disease, Osteoporosis

Foods: Fish, Shellfish

Miscellaneous: Alkaline diet, Epigenetics, Exercise, Genes, Lifestyle, Paleolithic

Vitamin D and Women’s Reproductive Health.

Posted on May 11, 2015 by Dr. Gary Pack

In North America and Western Europe very little vitamin D comes from the diet, and fish is a good source. Most of our vitamin D comes from sun exposure. The natural form of vitamin D is 1,25(OH)2D3. Blood testing is done on 25(OH)D3, with levels below 30 ng/ml being low. Vitamin D is important for […]

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Aluminum and Neurodegenerative Disease.

Posted on April 20, 2015 by Dr. Gary Pack

Although aluminum (Al) is the most common mineral in the Earth’s crust, it seems to have no useful function in plants or animals. Al was unknown in our environment until extraction for industrial uses began in the 1820’s. Humans get Al internally mostly from food. Now it is used in “food processing, manufacturing, medicines, cosmetics, […]

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