Cancer Chemoprevention by Dietary Polyphenols.

Posted on November 5, 2010 by Dr. Gary Pack

Cancer is believed to be the result of, both, genetics and epigenetics. Epigenetics has given new understanding to the development of cancers of all types. Epigenetic changes alter gene expression but don’t alter the sequence of DNA. Even though they are inheritable, they are reversible. They can be modified by diet, environment and pharmaceuticals. For […]

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Conditions: Apoptosis, Cancer, Cardiovascular disease, Gastroesophageal reflux, Hypermethylation, Hypomethylation, Liver cancer, Methylation, Neurodegenerative disease, Non-Hodgkin's lymphoma, Prenatal

Supplements: American ginseng (Panax quinquefolium), Amla berry, Bioflavonoids, Butyrate, Caffeic acid, Choline, Curcumin, EGCG (epigallocatechin gallate), Folic acid (folate), Genistein, Hesperidin, Isothiocyanates, Lycopene, Methionine, Resveratrol, S-adenosylmethionine (SAMe), Turmeric (Curcuma longa), Vitamin B, Vitamin B-12

Foods: Apple, Broccoli, Cashew, Cinnamon, Citrus fruit, Coffee, Fruits, Garlic, Grapes, Green tea (Camellia sinensis), Lignin, Matcha green tea, Soybeans, Tomatoes, Turmeric (Curcuma longa), Vegetables

Miscellaneous: Chemoprevention, Diet, DNA, Environment, Epigenetics, Genetics, Histone deacetylation, MicroRNA, Mutation, Omnivore, Pharmaceutical, Phenolics, Polyphenols, Vegan, Vegetarian

Nutrition and Cancer.

Posted on April 22, 2010 by Dr. Gary Pack

Dr. Donald Abrams learned to respect the power of herbs in medicine while doing research on use of marijuana in AIDS. He is an Integrative Oncologist who spends much of his time telling cancer patients about how alternative medicine can help in cancer treatment. He makes the following recommendations: 1. Eat more plant foods, including […]

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Anticancer Therapy and Histone Deacetylase Inhibitors.

Posted on July 18, 2009 by Dr. Gary Pack

Histone deacetylase inhibitors (HDACis) are a group of chemicals used in the treatment of cancer. They target histone deacetylase enzymes which are important in cancers. These enzymes are proteins which work “epigenetically” since they are able to change the expression of genes without altering the genes. They increase cell differentiation and apoptosis (programmed cell death). […]

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Carboxylic Acid Derivatives as Histone Deacetylase Inhibitors.

Posted on July 18, 2009 by Dr. Gary Pack

A group of 33 carboxylic acid related chemicals were tested for histone deacetylase (HDAC) inhibitor activity to learn which molecular structures are most active. Histone acetylation and deacetylation are important for gene expression. Deacetylation causes condensation of chromatin of the DNA. With condensation, information from the DNA is more difficult to access. Inhibition of deacetylation […]

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Conditions: Cancer, Inflammation, Neurodegeneration

Supplements: Butyrate, Caffeic acid, Chlorogenic acid, Curcumin

Miscellaneous: Acetylation, Deacetylation enzymes, Epigenetics, Histone deacetylase inhibitors, Polyphenols, Valproic acid (Valproate)

Hyaluronan and Hyaluronidase in Genitourinary Tumors.

Posted on April 25, 2009 by Dr. Gary Pack

The most common tumors in men are genitourinary, with prostate cancer predominating. Genitourinary cancers are fifth most common in women. This review covers the use of hyaluronan or hyaluronic acid (HA) in genitourinary tumors, including prostate, bladder, renal, testicular, penis and Wilms’ tumors. The connection between HA and genitourinary cancer has been studied for 50 […]

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Conditions: Angiogenesis, Bladder cancer, Breast cancer, Genitourinary cancer, Glioma, Kidney cancer, Metastases, Penis cancer, Prostate cancer, Squamous cell carcinoma, Testicular cancer, Wilms' tumor

Supplements: Chamomile (Matricaria chamomilla), Chondroitin sulfate, Hyaluronic acid

Miscellaneous: Epigenetics, Glycosaminoglycans, Hyaluronidase

EMF Exposure During Development.

Posted on February 15, 2008 by Dr. Gary Pack

Humans in modern societies living in industrialized countries are constantly exposed to an environment of elevated electromagnetic fields (EMF), both natural and man made. The levels and frequencies of exposure to EMF’s have greatly increased since the 1950’s, coming from electric power, radio, television, cell phones and transmitting towers. This paper reviews the history of […]

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Conditions: Chemical sensitivity, Electromagnetic fields, Sleep

Miscellaneous: Cell phones, Electricity, Electromagnetic fields (EMF), Epigenetics, Radio, Television, Transmitting towers

Evidence for Carcinogenic Activity of Bisphenol A.

Posted on December 19, 2007 by Dr. Gary Pack

The National Institutes of Health and the United States Environmental Protection Agency organized this review. This paper reviews the role of bisphenol A (BPA) in carcinogenesis in humans and animals. The study was about “endocrine disruptors.” Breast and prostate cancers continue to increase in frequency. This could be due to the increasing amounts of chemicals […]

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Conditions: Benign mammary tumor, Bisphenol toxicity, Breast cancer, Carcinogenesis, Fibroadenoma, Prostate cancer, Testicular cancer, Vaginal cancer

Miscellaneous: Bisphenol, Endocrine disruptors, Epigenetics, Estrogen

Diet, Exercise, Mental Health and Hormesis.

Posted on August 2, 2007 by Dr. Gary Pack

Hormesis is the “the capacity of low doses of a potentially harmful stimulus to promote beneficial changes in adaptive plasticity”. Diet, exercise and other lifestyle changes can alter the functioning of the brain through hormesis. A substance known as brain-derived neurotrophic factor (BDNF), found in the brain’s hippocampus, plays a part in synaptic plasticity, mental […]

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