Polyamines and Tumor Spread.

Posted on April 22, 2015 by Dr. Gary Pack

Polyamines, including spermine and spermidine, can be produced by nearly all cells, especially in those with rapid growth. High polyamine levels are seen in blood and urine of many cancer patients and can be eliminated by successful treatment of the tumors. However, they increase with tumor relapse. (The complete role of polyamines in cancer invasion […]

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Conditions: Cancer, Immune dysfunction, Metastases

Supplements: Arginine, S-adenosylmethionine (SAMe)

Miscellaneous: Invasion, Metalloproteinase, Microbiota, Polyamines, Proliferation, Spermidine, Spermine

Green Tea, Polyamines and Biogenic Amines.

Posted on January 14, 2014 by Dr. Gary Pack

Polyamines and biogenic amines are chemicals derived from amino acids. Polyamines are involved in intracellular signals. Biogenic amines function in intercellular communication. Epigallocatechin-3-gallate (EGCG) from green tea (Camellia sinensis) targets the pathways of biogenic amines and polyamines. This is of therapeutic interest in treating cancer. Tea is, also, a source of the amino acid, theanine, […]

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Conditions: Angiogenesis, Apoptosis, Cancer, Inflammation, Parkinson's disease, Vascular permeability

Supplements: Amino acids, Biogenic amines, EGCG (epigallocatechin gallate), Histamine, Theanine

Foods: Green tea (Camellia sinensis)

Miscellaneous: Biogenic amines, Caffeine, Cyclooxygenase, Dopamine, l-DOPA, Lipoxygenase inhibitor, Methylxanthine, Neurotransmitters, Polyamines, Putrescine, Serotonin, Spermidine, Spermine, Theobromine

Polyamines in Food and Ferments.

Posted on July 15, 2011 by Dr. Gary Pack

Spermidine, spermine, putrescine, cadaverine, agmatine and histamine are natural chemicals found in food. They are known as polyamines*, which are essential to normal cell processes. Polyamines are believed to be made of amino acids and are increased by fermentation. Putrescine can be produced from the amino acid ornithine. Polyamines are made by cells and they […]

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Conditions: Acidosis (acidity)

Supplements: Amino acids, Arginine, Histamine

Foods: Alcohol, Beer, Black tea (Camellia sinensis), Blue cheese, Cheddar cheese, Eggs, Fermented foods, Matcha green tea, Milk products, Miso, Mushrooms, Natto, Oolong tea, Oranges, Sake, Shiitake mushroom (Lentinus edodes), Soy sauce, Soybeans, Spinach, Tea (Camellia sinensis), Tempeh, Tofu, Vinegar (acetic acid)

Miscellaneous: Agmatine, Cadaverine, Enzymes, Ferment, Polyamines, Putrescine, Spermidine, Spermine

Arginase: a Key Enzyme in Allergic Asthma.

Posted on August 16, 2010 by Dr. Gary Pack

Allergic asthma causes obstruction of bronchi and airway hyperresponiveness (AHR.) Eventually, there are inflammation and remodeling of the airways. The enzyme, arginase, may play a part in this. Reduced availability of arginine may be involved, resulting in problems with bronchoconstriction from reduced levels of nitric oxide (NO.) Arginine deficiency results in increased levels of peroxynitrite, […]

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Conditions: Asthma, Bronchoconstriction, Inflammation

Supplements: Arginine, Citrulline, Ornithine, Rhubarb (Rheum rhabarbarum)

Miscellaneous: Arginase, Nitric oxide (NO), Nitric oxide synthetase, Peroxynitrite, Polyamines, Prolines, Putrescine, Spermidine, Spermine, Urea

Apoptosis and Proliferation by Tribulus Terrestris.

Posted on July 30, 2010 by Dr. Gary Pack

This study was done to learn about the anticancer effects of the saponins in Tribulus terrestris (TT) on normal human skin cells (fibroblasts) in the test tube. TT has been used to improve physical activity and sexual function in men. Saponins have anticancer effects. The anticancer effects of TT must be compared to the effects […]

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Conditions: Aging, Apoptosis, Breast cancer, Cell death, Erectile dysfunction, Hepatoma, Melanoma, Oral cancer, Ovarian cancer

Supplements: Puncture vine (Tribulus terrestus)

Foods: Green tea (Camellia sinensis), Mushrooms, Natto, Sake, Soybeans, Wine

Miscellaneous: Anticancer, Fibroblasts, Polyamines, Proliferation, Putrescine, Saponins, Spermidine, Spermine

Biogenic Amines in Wines.

Posted on April 26, 2007 by Dr. Gary Pack

Ten biogenic amines (ethanolamine, methylamine, tryptamine, 2-phenylethylamine, putrescine, cadaverine, histamine, tyramine, spermidine and spermine) were tested in red and white wines. The levels of amines change during the process of aging wine. Biogenic amines occur in protein-rich foods such as fish and meat, fermented foods like cheese and salami, beverages such as wine and beer […]

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Conditions: Cancer, Cardiac palpitations, Headache, Hypertension, Hypotension, Nausea

Foods: Green tea (Camellia sinensis), Mushrooms, Oranges, Red wine, Soybeans, Tea (Camellia sinensis), White wine, Wine

Miscellaneous: Amines, Polyamines

Decreased Polyamines with Aging.

Posted on September 14, 2006 by Dr. Gary Pack

The authors studied polyamine levels in mice at different ages to learn more about the changes that occur with natural aging. Polyamines stimulate the production of proteins and are necessary for proper organ function and include cadaverine, agmatine, spermine, spermidine, norspermidine and putrescine. The normal human polyamine synthesis is reduced with aging, therefore oral intake […]

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Conditions: Aging, Cancer

Supplements: Biogenic amines

Foods: Beans, Black rice, Cod, Corn, Eggplant, Fish sauce, Gorgonzola cheese, Green peppers, Green tea (Camellia sinensis), Liver, Mango, Mushrooms, Natto, Nuts, Oranges, Pickles, Pumpkin, Rice bran, Salmon, Smelt, Soy sauce, Soybeans, Wheat germ

Miscellaneous: Agmatine, Cadaverine, Norspermidine, Polyamines, Putrescine, Spermidine, Spermine

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