Dietary Polyphenols Protect Dopamine Neurons.

Posted on May 15, 2015 by Dr. Gary Pack

Flavonoids, found in fruits and vegetables, have been studied to see if they could reduce oxidative damage, which causes loss of dopamine production in the base of the brain. Oxidative stress is believed to contribute to the death of dopamine producing cells in Parkinson’s disease. (CoQ-10 is of benefit in Parkinsonism.) Various flavonoids, such as […]

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Conditions: Neuroprotection, Oxidative stress, Parkinson's disease

Supplements: Bioflavonoids, Chrysin, CoQ-10 (coenzyme Q-10), EGCG (epigallocatechin gallate), Kudzu (Pueraria lobata), Quercetin

Foods: Citrus fruit, Fruits, Grapefruit, Green tea (Camellia sinensis), Vegetables, Wine

Miscellaneous: Flavonoids, Polyphenols, Puerarin

New Treatments of Friedreich Ataxia.

Posted on April 8, 2014 by Dr. Gary Pack

Friedreich ataxia (FRDA) is an autosomal recessive disease in Caucasians. In this disease, there is loss of sensory neurons and degeneration of several nerve pathways of the spinal cord and brain. The result, eventually, is very poor control of voluntary movements. Some patients have loss of white matter of the brain, and some develop an […]

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Conditions: Cardiomyopathy, Cerebellar ataxia, Friedreich's Ataxia, Mitochondrial damage, Neurodegeneration, Oxidation

Supplements: Butyric acid, Carnitine, CoQ-10 (coenzyme Q-10), Creatine, Vitamin E

Miscellaneous: Erythropoietin, Frataxin, Histone deacetylase inhibitors, Idebenone

Coenzyme Q10 and Vitamin E Deficiency in Friedreich’s Ataxia.

Posted on August 5, 2010 by Dr. Gary Pack

Friedreich’s Ataxia (FRDA) is a hereditary, neurodegenerative disease. There is progressively severe incoordination of the arms and legs to the point that the patient becomes incapacitated. There is associated heart muscle disease. It has been found, previously, that CoQ-10 benefits patients with FRDA. High doses of Coenzyme Q-10 show marked benefit in most patients with […]

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Conditions: Friedreich's Ataxia, Neurodegenerative disease

Supplements: CoQ-10 (coenzyme Q-10), Vitamin E

Micronutrient Deficiencies in Heart Failure.

Posted on November 23, 2009 by Dr. Gary Pack

Heart failure is severely disabling, with high morbidity and mortality. Part of the problem is the heart’s constant need for a very large supply of raw materials to produce a great amount of energy. The heart is “rebuilt” from new chemicals every month. A deficiency of some nutrients is known to cause therapeutic failures, causing […]

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Conditions: Heart failure, Micronutrient deficiencies

Supplements: Carnitine, CoQ-10 (coenzyme Q-10), D-Ribose, Magnesium, Potassium, Propionyl-l-carnitine, Selenium, Taurine, Tyrosine, Vitamin B-1 (thiamine), Vitamin D, Zinc

Foods: Cooking oils, Fish, Legumes, Meat, Milk, Nuts, Poultry, Whole grains

Miscellaneous: LDL-cholesterol, Nutrients

Beta-Alanine and Neuromuscular Fatigue in the Elderly.

Posted on August 14, 2009 by Dr. Gary Pack

Carnosine (beta-alanyl-L-histidine) is a dipeptide (protein with two amino acids) and “an efficient hydrogen ion (H+) buffer.” Carnosine prevents intracellular acidosis and maintains normal muscle cell pH during heavy exercise by buffering action. Carnosine is in type I and II muscle fibers, especially in type II muscle fibers. Carnosine can be eaten in meat. The […]

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Conditions: Accidents, Acidosis (acidity), Aging, Elderly, Fatigue

Supplements: Beta-alanine, Carnosine, CoQ-10 (coenzyme Q-10)

Foods: Meat

Miscellaneous: Dipeptide, Muscle, Neuromuscular

Red Yeast Rice and Coenzyme Q(10) Levels.

Posted on February 22, 2008 by Dr. Gary Pack

Monacolin K, a component of red yeast rice, is a statin. Statin drugs have been used to lower cholesterol levels and triacylglyceride levels in congestive heart disease patients. A side effect of statins may be a reduction of blood levels of CoQ-10. CoQ-10 is involved in cell metabolism and is an antioxidant. In this study, […]

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Conditions: Congestive heart failure, Hypercholesterolemia, Hypertriglyceridemia, Myopathy

Supplements: CoQ-10 (coenzyme Q-10), Red yeast rice (Monascus purpureus)

Miscellaneous: Monacolin K, Statin drugs

Metabolic, Physical and Mental Therapy Before Cardiac Surgery.

Posted on June 7, 2007 by Dr. Gary Pack

Cardiac surgery results in stress to the metabolic, physical and mental systems. There is increased production of reactive oxygen species with cardiac surgery. The present study was done to evaluate a preoperative program of increased antioxidant intake, physical therapy and mental therapy. Sixteen patients were given supplements included Coenzyme Q(10,) 300 mg., alpha lipoic acid, […]

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Conditions: Heart disease, Stress, Surgery

Supplements: Alpha lipoic acid, Antioxidants, CoQ-10 (coenzyme Q-10), Magnesium orotate, Omega-3 fatty (linolenic) acid

Miscellaneous: Exercise, Malondialdehyde (MDA), Music, Physical therapy, Psychiatric therapy, Quality of life, Reactive oxygen species, Stretching

Skin Wrinkling: Can Food Make a Difference?

Posted on October 4, 2006 by Dr. Gary Pack

This article by Purba, et al, addresses whether skin wrinkling due to sun exposure can be correlated with the food eaten by people in different parts of world. Groups of people were studied in Australia, Greece, and Sweden, with some of the people being born in Greece but living in Australia and vise versa. The […]

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Conditions: Actinic damage, Aging, Gender, Skin wrinkling, Smokers

Supplements: Antioxidants, Calcium, Carotenoids, CoQ-10 (coenzyme Q-10), Iron, Magnesium, Milk thistle (Silybum marianum), Phosphorus, Plant sterols (Phytosterols), Retinol, Vitamin C (ascorbic acid), Vitamin E, Zinc

Foods: Alcohol, Berries, Broad beans, Butter, Cereals, Cheese, Cherries, Coffee, Dessert, Dried fruits, Eggplant, Fats, Fish, Fruits, Garlic, Leafy green vegetables, Legumes, Meat, Milk, Milk products, Monounsaturated fatty acid, Mousaka, Oils, Olive oil, Polyunsaturated oil, Prunes, Pudding, Strawberries, Sugars, Tea (Camellia sinensis), Vegetables, Yogurt

Miscellaneous: Australia, Caffeine, Greece, Polyphenols, Sun exposure, Sweden, UV (ultraviolet) light

Parkinson’s Disease and Oxidative Neurodegeneration.

Posted on March 10, 2006 by Dr. Gary Pack

Parkinson’s disease (PD) is the most common human movement disorder. Oxidative damage is seen in brain cells (neurodegeneration) in PD. Specific areas of the brain are involved, such as the substantia nigra (SN) of the brain, which is sensitive to oxidation and is often abnormal in PD. Nerves of the SN have dopamine activity. Most […]

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Conditionally Essential Nutrients in Cardiovascular Disease.

Posted on January 29, 2006 by Dr. Gary Pack

Conditionally essential nutrients (CENs) are compounds produced in our bodies in sufficient amounts under usual conditions. The amount produced is not sufficient under the conditions of disease and these nutrients are required for recovery from disease. The primary CENs for cardiovascular disease are l-arginine, l-carnitine, propionyl-L-carnitine and CoQ-10 (ubiquinone.) These CENs are supported by extensive […]

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Conditions: Angina, Cardiovascular disease, Heart failure, Hyperlipidemia, Hypertension, Intermittent claudication, Myocardial infarction, Nutrient deficiency

Supplements: Alpha lipoic acid, Arginine, Betaine (trimethylglycine) (TMG), Carnitine, Chondroitin sulfate, CoQ-10 (coenzyme Q-10), D-Ribose, Propionyl-l-sulfate, Taurine

Miscellaneous: Conditionally essential nutrients, Nutrients

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