Natural Angiogenesis Inhibitors and Cancer-Part 2.

Posted on July 5, 2015 by Dr. Gary Pack

Adipocytokines are polypeptides produced by fat cells.They are associated with obesity, hyperinsulinemia, chronic vascular disease and cancer.The adipocytokines which promote angiogenesis (the growth of new blood vessels) include vascular endothelial growth factor (VEGF,) hepatocyte growth factor (HGF,) leptin, tumour necrosis factor alpha, heparin-binding epidermal growth factor, insulin-like growth factor and interleukin-6 (IL-6.) Whole plant extracts […]

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Conditions: Angiogenesis, Apoptosis, Bladder cancer, Breast cancer, Cancer, Chronic myelogenous leukemia, Hyperinsulinemia, Inflammation, Multidrug resistance (MDR), Obesity, Vascular disease

Supplements: Asian ginseng (Panax ginseng), Curcumin, Daidzein, Dong quai (Angelica sinensis, EGCG (epigallocatechin gallate), Eicosapentanoic acid (EPA), European mistletoe (Viscum album), Feverfew (Tanacetum parthenium), Genistein, Ginger (Zingiber officinale), Ginseng, Grape seed extract, Hibiscus (Hibiscus sabdariffa), Holy basil (Ocimum sanctum), Lapacho (Pau d'arco), Omega-6 fatty (linoleic) acid, Pau d'arco (Tabebuia avellanedae), Quercetin, Red sage (Salvia miltiorrhiza), Resveratrol, Rosemary (Rosmarinus officinalis), Skullcap (Scutellaria baicalensis), Turmeric (Curcuma longa)

Miscellaneous: Anti-angiogenesis, Anticoagulant, Arachidonic acid, COX-2, COX-2 inhibitor, Epidermal growth factor, Prostaglandins, Tyrosine kinase, VEGF (vascular endothelial growth factor)

COX Inhibitors in Ovarian Cancer.

Posted on April 27, 2015 by Dr. Gary Pack

COX-1 (cyclooxygenase-1) and COX-2 (cyclooxygenase-2) enzymes control the onset and progression of a number of cancers. COX-1 and COX-2 inhibitors are well known anti-inflammatory enzymes found in plants. Pharmaceutical versions of these two inhibitors are available. NSAIDs (nonsteroidal anti-inflammatory drugs), such as aspirin, are believed to inhibit cancer by inhibition of COX activity, and long-term […]

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Conditions: Apoptosis, Cancer, Inflammation, Ovarian cancer

Miscellaneous: Aspirin, Celecoxib, Chemoprevention, COX-1, COX-2, COX-2 inhibitor, Ibuprofen, Proliferation, Synergistic

Anti-Angiogenesis Review.

Posted on May 5, 2012 by Dr. Gary Pack

Angiogenesis is a normal process of forming new blood vessels. It takes place in growth, menstrual cycles, healing, etc. It is necessary for cancers to grow and to metastasize. It occurs in macular degeneration and hinders the vision. Blockers of angiogenesis are beneficial in cancer, macular degeneration and other disease processes. Dr. Judah Folkmann studied […]

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Conditions: Angiogenesis, Cancer, Wounds

Supplements: Andrographis (Andrographis paniculata), Arginine, Asian ginseng (Panax ginseng), Benfotiamine, Bilberry (Vaccinium myrtillus), Cinnamon (Cinnamomum cassia), Copper, Docosahexanoic acid (DHA), Dong quai (Angelica sinensis, Eicosapentanoic acid (EPA), European mistletoe (Viscum album), Ginger (Zingiber officinale), Ginkgo (Ginkgo biloba), Gotu kola (Centellla asiatica), Green tea, Holy basil (Ocimum sanctum), Hops (Humulus lupulus), Licorice (Glycyrrhiza glabra), Lysine, Milk thistle (Silybum marianum), Omega-3 fatty (linolenic) acid, Proanthocyanidines, Quercetin, Red sage (Salvia miltiorrhiza), Resveratrol, Selenium, Skullcap (Scutellaria baicalensis), St. John's Wort (Hypericin perforatum), Turmeric (Curcuma longa), Vitamin D, Wormwood (Artemisia annua), Zinc

Foods: Broccoli, Brussel's sprouts, Cruciferous vegetables, Green tea (Camellia sinensis), Matcha green tea, Mate (Ilex paraguayensis)

Miscellaneous: COX-2, COX-2 inhibitor, Exercise, Folkman (Dr. Judah), Li (Dr. William), Proton pump inhibitors, Vegan

Endometriosis Review.

Posted on May 8, 2011 by Dr. Gary Pack

Endometriosis is a pelvic inflammatory disease causing pelvic pain and infertility. It is an estrogen-dependent disease, made worse by increased environmental estrogens. In endometriosis, uterine tissue can be found outside the uterus. Endometriosis occurs during the reproductive years and is progressive. One-half of women with infertility have endometriosis. Kudzu herb produces an isoflavone, puerarin, an […]

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Curcumin for the Prevention of Colorectal Cancer.

Posted on April 22, 2011 by Dr. Gary Pack

Aberrant crypt foci (ACF) are small lesions of the colorectal region which may be markers of colon carcinogenesis. ACF are found in the rectums of current and former tobacco smokers. Curcumin is a natural chemical derived from the turmeric plant. It has anti-inflammatory, antioxidant, and anticancer properties. Curcumin prevents the production of two chemicals called […]

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Conditions: Abberant cryptic foci, Carcinogenesis, Colon cancer, Diarrhea, Gastroesophageal reflux

Supplements: Curcumin, Turmeric (Curcuma longa)

Miscellaneous: COX-1, COX-2, COX-2 inhibitor, Eicosanoids, Prostaglandins

Phytosome Complexes of Silymarin, Curcumin, Etc.

Posted on August 9, 2010 by Dr. Gary Pack

One class of very useful plant medicines is made up of polyphenols, mostly flavonoids. Polyphenols absorb poorly into water or lipids. The phytosome forms of polyphenols have improved oral absorption and are safe. They are used as anti-inflammatories, anti-neoplastics, for detoxification and for weight loss.Polyphenols bind strongly to phospholipids, even in intact plant tissue. Phosphatidylcholine […]

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Hop and Multipotent Bioactive Compounds.

Posted on June 27, 2009 by Dr. Gary Pack

Hop (Humulus lupulus) is a plant which contains many bitter chemicals. Hops contain weak acids which have many actions, such as anticancer, antioxidant, anti-angiogenesis, apoptotic and detoxification. They are anti-inflammatory and work against diabetes mellitus, cardiovascular disease and the metabolic syndrome. Ninety percent of hops go to the brewing industry. Female hop plants form cones […]

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COX-2 and Neovascularization in Endometriosis..

Posted on January 8, 2007 by Dr. Gary Pack

The cyclooxygenase-2 (COX-2) enzyme may play a role in endometriosis by altering angiogenesis and proliferation. The COX-2 enzyme increases the production of prostaglandins, which cause cell proliferation, apoptosis, angiogenesis and tumor invasiveness. Previous studies suggest a difference between endometriosis of the uterus and of other parts of the body. COX-2 inhibitors reduce angiogenesis and cell […]

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Conditions: Angiogenesis, Apoptosis, Cancer, Endometriosis

Supplements: Echinacea sp., Hops (Humulus lupulus), Nettles (Urtica dioica)

Miscellaneous: COX-2, COX-2 inhibitor

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