Roundup and Toxicity.

Posted on March 1, 2011 by Dr. Gary Pack

Glyphosate is sold under the name Roundup. Glyphosate-based herbicides (GBHs) are frequently associated in agriculture with genetically modified organisms (GMO,) such as soy beans. This combination is widely used in South America with little study of the impact on the environment or on the health of people. There have been numerous studies outside of the […]

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Conditions: Craniofacial defects, Fetal life, Malformed babies

Foods: Corn, Soybeans

Miscellaneous: African clawed frog (Xenopus laevis), Aromatase enzyme, Blood, Endocrine disruptors, Estrogen, Genetically modified organisms (GMOs), Heart, Kidney, Liver, Retinoic acid, Roundup herbicide (glyphosate), Testosterone

Goldenseal as a LDL-Lowering Agent.

Posted on November 5, 2007 by Dr. Gary Pack

Berberine (BBR) is the active ingredient in goldenseal (Hydrastis canadensis or the Chinese huanglian) root and in coptis (Coptis chinensis). BBR is an alkaloid that stabilizes mRNA to increase the production of a protein, called low-density lipoprotein receptor (LDLR), which takes up LDL-cholesterol. About 70% of LDL-cholesterol is removed from the blood by the liver […]

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Conditions: Cardiovascular disease, Hypercholesterolemia

Supplements: Coptis (Coptis chinensis), Goldenseal (Hydrastis canadensis)

Miscellaneous: Berberine, Cholesterol, Hepatoprotective, Isoquinoline, LDL-cholesterol, Liver, RNA, Triglycerides

Silibinin and Hepatocellular Carcinoma.

Posted on March 6, 2007 by Dr. Gary Pack

Hepatocellular carcinoma (HCC) of the liver, which has no current effective treatment, is the world’s second most common recurrent cancer, with one million people dying of HCC annually worldwide. The treatment is poor at present because of drug resistance and the severe toxicity of the drugs used for chemotherapy. HCC cells are especially resistant to […]

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Conditions: Apoptosis, Bladder cancer, Breast cancer, Cancer, Chemotherapy, Colon cancer, Fungal infection, Hepatitis, Hepatitis B, Hepatitis C, Hepatocellular cancer, Lung cancer, Multidrug resistance (MDR), Prostate cancer, Skin cancer

Supplements: Milk thistle (Silybum marianum), Silibinin, Silymarin

Miscellaneous: Aflatoxin, Aspergillus mold, Liver

HDL and Cardiovascular Disease.

Posted on June 29, 2006 by Dr. Gary Pack

Fat and lipid abnormalities are the major risk factors for cardiovascular disease. The use of the pharmaceutical statin drugs has been shown to reduce the risk factors for cardiovascular disease by reducing LDL cholesterol. Statins are believed to have reduced the incidence of coronary events, such as heart attacks, but atherosclerotic disease continues to be […]

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Conditions: Arteriosclerosis (atherosclerosis), Cardiovascular disease, Coronary heart disease, Death, Flushing, Heart attack, Hyperuricemia, Liver toxicity, Tangier's disease

Supplements: Vitamin B-3 (niacin) (nicotinic acid)

Foods: Olive oil

Miscellaneous: Bile, Cholesterol, Fats, HDL-cholesterol, LDL-cholesterol, Lipids, Liver, Nitric oxide synthetase, Prostaglandins, Statin drugs

Copper and Iron Interactions.

Posted on March 29, 2006 by Dr. Gary Pack

There is a recognized and poorly understood relationship between iron and copper metabolism in our bodies. Some cases of iron deficiency anemia cannot be relieved by the consumption of iron but can be successfully treated by the consumption of copper. The best current explanation of the relationship of iron to copper is based on the […]

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Conditions: Ceruloplasmin deficiency, Copper deficiency, Iron deficiency, Iron deficiency anemia, Malnutrition

Supplements: Copper, Iron

Miscellaneous: Bile, Ceruloplasmin, Liver, Red blood cells

Vitamin D, the Lactating Mother and the Nursing Infant.

Posted on March 16, 2006 by Dr. Gary Pack

The daily dose of vitamin D advised for mothers during lactation are currently 400 IU/day. The authors say this dose is too low, especially for dark pigmented people. Rickets in infancy is an increasing problem in the breastfed children because of the current fear of the sun and of skin cancer. Vitamin D is converted […]

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Conditions: Breastfeeding, Hypercalciuria, Lactation, Rickets, Skin cancer

Supplements: Vitamin D

Foods: Milk

Miscellaneous: Kidney, Liver, Sun exposure

Copper in Nutrition.

Posted on March 12, 2006 by Dr. Gary Pack

The intestinal absorption of copper depends on the circulation between the intestine and the liver and on the bile secretion. This controls the copper nutritional status of the person. Some of the factors that influence copper absorption are proteins, amino acids, fructose, ascorbic acid, phytates, divalent cations, etc. This is a foreign language article and […]

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Supplements: Copper, Vitamin C (ascorbic acid)

Miscellaneous: Amino acid, Bile, Fructose, Intestine, Liver, Phytates (phytic acid), Protein

Amiodarone Metabolism Inhibition by Grapefruit Juice.

Posted on January 26, 2006 by Dr. Gary Pack

Amiodarone is a drug for the treatment of atrial fibrillation, which is metabolized (broken down chemically) by a major liver enzyme that also metabolizes many anti-cancer drugs. Grapefruit juice is known to block this enzyme, resulting in failure of metabolism if amiodarone given at the same time. This combination can also result in very high […]

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Conditions: Atrial fibrillation

Foods: Grapefruit juice

Miscellaneous: Amiodarone, Anticancer drugs, Liver

Copper Absorption and Bioavailability.

Posted on June 14, 2005 by Dr. Gary Pack

Thirty to forty percent of the copper we ingest is absorbed. With aging, the loss of efficiency of the liver may result in higher copper levels because elimination of excess copper depends on the bile production. Dietary fiber can alter copper levels in different ways depending on the amount of fiber ingested. Malabsorption diseases and […]

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Conditions: Aging, Cancer, Cardiovascular disease, Copper deficiency, Gastrointestinal disease, Malabsorption, Wilson's disease

Supplements: Amino acids, Citric acid (citrate), Copper, Dietary fiber, Iron, Malic acid, Molybdenum, Vitamin C (ascorbic acid), Zinc

Foods: Vegetables

Miscellaneous: Bile, Liver

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