Milk Thistle Phytosome.

Posted on November 7, 2007 by Dr. Gary Pack

Milk thistle (Silybum marianum), an anti-oxidant, contains flavonoids that protect the liver. The liver detoxifies hormones and other chemicals produced in the body and is an easy target for damage by any toxins ingested. Silymarin is the active extract of Milk thistle which contains the following flavonoids: Silibin, silydianin and silychristin. Silibin is a flavonolignan. […]

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Conditions: Alcoholic hepatitis, Liver protection, Liver toxicity, Viral hepatitis

Supplements: Antioxidants, Bioflavonoids, Curcumin, Glutathione, Grape seed extract, Green tea, Lignans, Milk thistle (Silybum marianum), Phosphatidylcholine, Phytosomes, Silibinin, Silymarin

Foods: Soy

Miscellaneous: Phospholipids

Silymarin is Hepatoprotective in Cholestasis.

Posted on September 20, 2007 by Dr. Gary Pack

Silymarin (SIL) is an extract of Milk thistle (Silybum marianum), which has been used for 2000 years. Milk thistle has been used since the 16th century for liver disease and SIL has been marketed since 1969. SIL is a standard extract of the Milk thistle fruit and seed and standardized Milk thistle is 70% SIL. […]

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Antioxidant and Anti-Inflammatory Activity of Andrographis.

Posted on May 29, 2007 by Dr. Gary Pack

An oxygen free radical (OFR) is the form of oxygen that has one unpaired electron and is very reactive. There are other forms of highly reactive oxygen, which do not have unpaired electrons known as reactive oxygen species (ROS.) ROS include singlet oxygen, hydrogen peroxide and hydroxyl radicals, which are constantly being produced by ionizing […]

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Dietary Flavonoids and Leukemia Cells.

Posted on May 25, 2007 by Dr. Gary Pack

Annually about 10 million people develop cancer and about 6.2 million people die of cancer worldwide. Cancer cells have altered chemical pathways that lead to rapid growth and division of cells and reduced apoptosis (cell suicide). Overriding these functions can be therapeutic in patients with cancer and the proteasome pathway plays a role in these […]

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Phyllanthus Niruri in Urolithiasis.

Posted on March 2, 2007 by Dr. Gary Pack

Phyllanthus niruri (Pn) is an herb from Brazil, belonging to the Euphorbiaceae family of plants, that is known to prevent the growth of calcium oxylate (CaOx) urinary stones. The present study of rats followed the progression of stones after a CaOx “seed stone” was placed in the urinary bladder. Treatment with Pn was started immediately […]

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Conditions: Hypercalciuria, Kidney stones, Urinary stones (urolithiasis)

Supplements: Bioflavonoids, Lignans, Stone breaker (Phyllanthus niruri)

Miscellaneous: Alkaloids, Brazil, Calcium oxylate, Flavonoids, Triterpenes, Urinary bladder

Hypouricemic Agent: Mulberry Twig

Posted on December 15, 2006 by Dr. Gary Pack

Hyperuricemia is associated with gout and other diseases. The incidence of gout has doubled in the past 20 years and 80 to 90% of patients with gout do not excrete uric acid normally. Lowering of the uric acid can be accomplished by xanthine oxidase (an enzyme) inhibitors and renal ureate reabsorption blockers. Allopurinal is the […]

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Conditions: Bone marrow suppression, Gastrointestinal irritation, Gout, Hyperuricemia, Skin rash

Supplements: Antioxidants, Astragalus (Astragalus membranaceus), Bioflavonoids, Morin, White mulberry (Morus alba)

Foods: Black tea (Camellia sinensis), Cocoa, Figs

Miscellaneous: Allopurinal, Traditional Chinese Medicine, Uric acid (urate), Xanthine oxidase, Xanthine oxidase inhibitors

Hyperuricemia Induces Endothelial Dysfunction.

Posted on December 7, 2006 by Dr. Gary Pack

In humans an enzyme called uricase has mutated, resulting in higher uric acid levels. Hyperuricemia is connected to cardiovascular and kidney disease. This could be the result of reactive oxygen species (ROS) causing damage to the inner endothelial lining of blood vessels. The effect of the enzyme xanthine oxidase is the production of uric acid […]

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Uric Acid in Fructose-Induced Metabolic Syndrome.

Posted on December 7, 2006 by Dr. Gary Pack

The metabolic syndrome is the cause of a worldwide epidemic consisting of: Obesity, poor tolerance to glucose, hyperinsulinemia, hyperuricemia (high serum uric acid,) hypertriglyceridemia, and hypertension, which are all risk factors for cardiovascular disease. The metabolic syndrome is seen in 27% of the population of the United States and the diagnosis of metabolic syndrome triples […]

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Low-Dose Toxins and Adaptive Stress Responses.

Posted on November 16, 2006 by Dr. Gary Pack

People with diets rich in fruits and vegetables have a reduced risk of developing various diseases, including neurodegenerative diseases. Some of the chemicals in these beneficial foods are antioxidants, which are called plant “biopesticides” and are believed to be chemical defenses developed by plants to protect themselves from insects and other invaders. At much lower […]

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Xanthine Oxidase and Idiopathic Pulmonary Arterial Hypertension.

Posted on October 15, 2006 by Dr. Gary Pack

Idiopathic pulmonary arterial hypertension (IPAH) is believed to be made worse by oxidative stress. The enzyme, xanthine oxidase, contributes to that oxidative stress, causing damage to arteries by increasing uric acid levels. High uric acid levels (hyperuricemia) in IPAH are believed to be the result of increased xanthine oxidase activity. The xanthine oxidase enzyme is […]

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