Carboxylic Acid Derivatives as Histone Deacetylase Inhibitors.

Posted on July 18, 2009 by Dr. Gary Pack

A group of 33 carboxylic acid related chemicals were tested for histone deacetylase (HDAC) inhibitor activity to learn which molecular structures are most active. Histone acetylation and deacetylation are important for gene expression. Deacetylation causes condensation of chromatin of the DNA. With condensation, information from the DNA is more difficult to access. Inhibition of deacetylation […]

View Post

Conditions: Cancer, Inflammation, Neurodegeneration

Supplements: Butyrate, Caffeic acid, Chlorogenic acid, Curcumin

Miscellaneous: Acetylation, Deacetylation enzymes, Epigenetics, Histone deacetylase inhibitors, Polyphenols, Valproic acid (Valproate)

Alzheimer’s Disease and Vascular Dementia Treatment with Huperzine A.

Posted on March 28, 2009 by Dr. Gary Pack

Huperzine A (HupA) comes from the Chinese medicine Huperzia serrata (Qian Ceng Ta). It is an acetylcholinesterase (AChE) inhibitor, which slows AD symptoms. AChEIs have been shown to increase learning and memory in Alzheimer’s disease and vascular dementia (VaD.) (HupA is from lycopodium.) The present study reviews the protective functions of HupA, such as controlling […]

View Post

Conditions: Alzheimer's disease, Apoptosis, Dementia, Inflammation

Supplements: Cell Guard, Glutathione peroxidase, Lycopodium (Huperzia serrata), Superoxide dismutase (SOD)

Miscellaneous: Acetylcholinesterase (ACE) inhibitior, Amyloid

Omega-3, DHA, and EPA for Cognition, Behavior, and Mood.

Posted on March 14, 2009 by Dr. Gary Pack

Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are omega-3 fatty acids which are conditionally beneficial. They function on cell membranes where they are attached to phospholipids. Cell membranes are the “pacemakers of metabolism.” Increasing the unsaturated fatty acids in the membranes improves “fluidity” of cell membranes and improves cellular functioning. This is important in such […]

View Post

Nutrition and Autoimmune Disease.

Posted on December 18, 2008 by Dr. Gary Pack

Rheumatoid arthritis (RA) is an inflammatory condition of the joints. It is believed to be an autoimmune disease. It is characterized by the movement of lymphocytes and other inflammatory cells into the joint tissues and fluids, causing pain and swelling. The main dietary omega-6 fatty acid, arachidonic acid, produces inflammatory eicosanoid chemicals in cells. High […]

View Post

Conditions: Autoimmune disease, Inflammation, Pain, Rheumatoid arthritis

Supplements: Docosahexanoic acid (DHA), Eicosapentanoic acid (EPA), Fish oil, Omega-3 fatty (linolenic) acid, Omega-6 fatty (linoleic) acid

Foods: Fish

Miscellaneous: Anti-inflammatory, Arachidonic acid, Eicosanoids, Prolactin, Resolvins

Anti-Tumor Activity of Andrographis Paniculata.

Posted on June 3, 2008 by Dr. Gary Pack

Andrographolide is a chemical called a diterpine lactone found in the plant called Andrographis paniculata. This plant has been shown, scientifically, to have anti-inflammatory activity, which is an oriental traditional medicine used to treat inflammation. Injections of derivatives of andrographolide, called Lianbizhi, have been found to inhibit gastric, liver and lung cancers in living patients. […]

View Post

Conditions: Angiogenesis, Apoptosis, Cancer, Inflammation, Prostate cancer

Supplements: Andrographis (Andrographis paniculata)

Miscellaneous: Andrographolide, Antioxidant, Ayurvedic medicine, Diterpene, Kalmegh, Lianbizhi, VEGF (vascular endothelial growth factor)

Lactoferrin Augments Cancer Chemotherapy.

Posted on February 15, 2008 by Dr. Gary Pack

Body secretions contain lactoferrin (Lf,) an iron-containing protein which is a natural defense to tissues commonly exposed to bacteria. Lf has been shown to have the following functions: 1. Regulation of intestinal iron absorption. 2. Promotion of intestinal cell growth. 3. Protection from bacterial infections. 4. Promotion of white cell growth. 5. Control of the […]

View Post

Conditions: Anemia, Arthritis, Asthma, Bladder cancer, Chemotherapy, Colon cancer, Esophageal cancer, Inflammation, Inflammatory bowel disease, Lung cancer, Neurodegeneration, Tongue cancer

Supplements: Lactoferrin

Pancreatic Cancer Prevention, Curcumin and Omega-3.

Posted on February 7, 2008 by Dr. Gary Pack

Pancreatic adenocarcinoma is the fourth most frequently diagnosed cancer for both men and women in the United States and the chance for survival for these cancers is extremely poor. Malisetty’s research investigated the effects of fish oil, containing docosahexaenoic acid (DHA), and curcumin on pancreatic cancer in mice. Curcumin, an extract of turmeric (Curcuma longa), […]

View Post

Conditions: Apoptosis, Inflammation, Pancreatic adenocarcinoma, Pancreatic cancer

Supplements: Curcumin, Docosahexanoic acid (DHA), Fish oil, Omega-3 fatty (linolenic) acid, Omega-6 fatty (linoleic) acid, Turmeric (Curcuma longa)

Miscellaneous: Anti-inflammatory, Eicosanoids

Anticonvulsant Effects of Nigelia Sativa Seeds.

Posted on December 13, 2007 by Dr. Gary Pack

Thymoquinone is the major component of the seeds of black cumin (Nigelia sativa), which grows in countries around the Mediterranean Sea, is part of the Ranunculaeae family. It has been shown to be antihistaminic, antihypertensive, analgesic, antioxidant, anti-inflammatory, antibacterial, antifungal, antihelminic and antitumour. The major effects are believed to be due to quinones, of which […]

View Post

Conditions: Bacterial infection, Cancer, Fungal infection, Hypertension, Inflammation, Seizures

Supplements: Black seed (Nigella sativa), Gamma amino butyric acid (GABA)

Miscellaneous: Analgesic, Anti-inflammatory, Antibacterial, Anticancer, Antifungal, Antihelminic, Antihistaminic, Antihypertensive, Antioxidant, Mediterranean Sea, Muscle, Ranunculaceae fam., Thymoquinone

Antiplasmodial and Antitumor Activity of Artemisinin.

Posted on December 8, 2007 by Dr. Gary Pack

The active chemical of Artemisia annua (qinhao, sweet wormwood) is artemisinin, which is a sesquiterpene lactone. (Such compounds are anti-inflammatory.) Artemisia belongs to the family Asteraceae and was first described in China in 168 B.C. Artemisinin is antimalarial and anticancer. The anticancer effect is in the range of concentration between nanomolar and micromolar blood levels. […]

View Post

Lactoferrin and Stem Cell Transplants.

Posted on September 13, 2007 by Dr. Gary Pack

Lactoferrin is a glycoprotein of the innate immune system and its receptors are found in many tissues of the body. Lactoferrin and its derivatives have the following properties: 1. Broad spectrum anti-microbial activity. 2. Anti-tumor activity with apoptosis in cancer cells. 3. Regulation of cell growth and differentiation. 4. Modulation of inflammatory, humoral and cellular […]

View Post

«‹7 8 9 10 11 ›»

Email:
First Name:	Last Name:
Zip Code:

Library: Viewing all articles on "Inflammation"