Urate Oxidase Activity in Hominoids and Uric Acid..

Posted on January 25, 2012 by Dr. Gary Pack

Uricase (urate oxidase) is an enzyme that stimulates the oxidation of uric acid to allantoin. The lack of this enzyme in humans results in high uric acid blood levels (hyperuricemia) and gout. Uric acid levels in humans can be 10 times high as in other animals. Reduced urate oxidase activity in humans is due to […]

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Conditions: Cancer, Gout, Gouty arthritis, Hyperuricemia, Mutation, Oxidative damage, Vascular disease

Supplements: Antioxidants, Astragalus (Astragalus membranaceus), Bioflavonoids, White mulberry (Morus alba)

Foods: Black tea (Camellia sinensis), Cocoa

Miscellaneous: Brain, DNA, Polyphenols, Purines, Uric acid (urate), Uricase (urate oxidase), Xanthine oxidase, Xanthine oxidase inhibitors

Diet in Rheumatic Disease.

Posted on July 18, 2011 by Dr. Gary Pack

Gout, an inflammatory disease of hyperuricemia (high uric acid,) is caused by monosodium urate crystals in joints and other tissues. It is associated with the metabolic syndrome and the consumption of high purine foods. The risk of gout is increased by high protein diets and by alcohol. Low purine diets are difficult for many people […]

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Conditions: Fibromyalgia, Gout, Hyperuricemia, Metabolic syndrome, Osteoarthritis, Rheumatoid arthritis

Supplements: Antioxidants, Omega-3 fatty (linolenic) acid, Omega-6 fatty (linoleic) acid, Omega-9 fatty acid, Probiotics, Vitamin C (ascorbic acid), Vitamin E

Foods: Bacon, Beef, Beer, Black currants, Broccoli, Brussel's sprouts, Cabbage, Chocolate, Citrus fruit, Coffee, Corn, Dairy, Eggs, Fish, Fructose, Green peppers, Meat, Milk, Nut oil, Nuts, Olive oil, Oranges, Parsley, Pork, Potatoes, Rose hips, Rye, Safflower oil, Shrimp, Strawberries, Sunflower seeds, Vegetable oils, Vegetables, Wheat, Whole grains, Wine

Miscellaneous: Aspartame, Caffeine, Elimination diet, Food coloring, Mediterranean diet, Monosodium glutamate, Purines, Uric acid (urate)

Meltdown in Fukushima: The Human Factor.

Posted on June 20, 2011 by Dr. Gary Pack

In 2011, when disaster hit at Fukushima, the Prime Minister of Japan reported that his government was on full alert at the Fukushima Daiichi nuclear Power Station. The accident was a previously unknown event of an earthquake followed by a tsunami–followed by a nuclear accident. The Japanese government’s reaction followed the known stages of grief. […]

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Conditions: Anger, Arthritis, Fibromyalgia, Gout, Grief, Muscle pain, Neuralgia, Neuritis

Supplements: Iodine

Miscellaneous: Air, Cesium, Chernobyl, Earthquake, Fukushima, Icarus, Ikaria, Ionizing radiation, Japan, Radiation, Radioactive, Radioactive iodine, Suevert (Dr. Rolf), Tsunami, U.S. Department of Energy, Uric acid (urate)

Kudzu Review.

Posted on May 8, 2011 by Dr. Gary Pack

Kudzu (Pueraria Montana or lobata,) an Asian herb, was brought to the U.S. for medicine and as food for animals. It is a traditional medicine for alcohol abuse. Kudzu grows so well in the U.S. that the vines grow into and shade the native trees, endangering the forests. Kudzu is a legume which fixes nitrogen […]

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Conditions: Aging, Breast cancer, Cirrhosis, Endometriosis, Fatty liver (hepatic steatosis), Hearing loss (presbycusis), Hypertension, Menopause, Parkinson's disease

Supplements: Kudzu (Pueraria lobata), Puerarin, Thai kudzu (Pueraria mirifica)

Miscellaneous: Aromatase inhibitor, Estrogen replacement therapy, Nitric oxide (NO), Ozone, Tectoridin, Uric acid (urate), Xanthine oxidase

Gout and Cancer.

Posted on January 6, 2010 by Dr. Gary Pack

Gout patients have an increased risk of cancer because of the high frequency of heavy alcohol intake and obesity, which are often associated. High uric acid (hyperuricemia) should have a protective effect by cancer prevention since uric acid is an antioxidant. To evaluate the relationship between gout, cancer and hyperuricemia, the authors studied cancer incidence […]

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Advances in Medical Stone Management Over 35 Years.

Posted on July 17, 2009 by Dr. Gary Pack

The author has worked on the problem of urolithiasis (urinary stones) for 35 years, writing 94 articles. He has studied hypocitraturia, hypercalciuria and the links between gouty stones, obesity and insulin resistance. This article reviews progress of the past 35 years. Dr. Pak’s main interests have been the causes of stones and the prevention of […]

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Hypocitraturia and Potassium Citrate.

Posted on February 29, 2008 by Dr. Gary Pack

Potassium citrate is the most commonly used therapy for low urinary citrate levels (hypocitraturia). Hypocitraturia is seen in 13-63% of patients with recurrent urinary stones. Potassium citrate is the common therapy for kidney stones (nephrolithiasis) caused by calcium oxylate, uric acid or cystine. Citrate alkalinizes urine, prevents crystal formation and chelates calcium. Chronic diarrhea reduces […]

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Conditions: Diarrhea, Hypocitraturia, Kidney stones, Muscle weakness, Urinary stones (urolithiasis)

Supplements: Potassium citrate

Miscellaneous: Calcium oxylate, Cystine, pH, Uric acid (urate)

Hyperuricemia Review.

Posted on February 6, 2008 by Dr. Gary Pack

Hyperuricemia (high blood uric acid) a health issue apart from gout. Gout is the best known result of high uric acid blood levels in humans, causing painful, swollen joints. Gout symptoms come from deposits of uric acid crystals in joints of colder parts of the body. Hyperuricemia is from excess uric acid production or insufficient […]

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Conditions: Abdominal obesity, Cancer, Cardiovascular disease, Gout, Hypertension, Hypertriglyceridemia, Hyperuricemia, Insulin resistance, Lead toxicity (plumbism), Lifestyle, Metabolic syndrome, Pulmonary arterial hypertension, Urinary stones (urolithiasis), Weight loss

Supplements: Arginine, Astragalus (Astragalus membranaceus), Bioflavonoids, Chelation therapy, Kudzu (Pueraria lobata), Lignans, Plumbum metallicum homeopathic, Potassium citrate, Quercetin, Stone breaker (Phyllanthus niruri), Vitamin B-3 (niacin) (nicotinic acid), White mulberry (Morus alba)

Foods: Alcohol, Anchovies, Asparagus, Bacon, Beef, Beer, Black tea (Camellia sinensis), Bread, Cauliflower, Chicken, Cocoa, Duck, Figs, Fructose, Fruit juices, Glucose, Grapefruit juice, Herring, High fructose corn syrup, Kidney, Kidney beans, Lamb, Lemon juice, Lima beans, Liver, Mackerel, Mushrooms, Orange juice, Peas, Pork, Sardines, Scallops, Soft drinks, Spinach, Sweetbreads, Turkey, Whole grains, Yeast

Miscellaneous: Allopurinal, Apigenin, Gasoline, HDL-cholesterol, Homeopathy, Kaempferol, Morin, Nitric oxide (NO), Polyphenols, Puerarin, Purines, Uric acid (urate), Xanthine oxidase

The Metabolic Syndrome and Serotonin Activity.

Posted on May 28, 2007 by Dr. Gary Pack

The complete cause of the metabolic syndrome is not known at the present time. The metabolic syndrome is demonstrated by abdominal obesity, altered glucose metabolism, abnormal lipid metabolism and high blood pressure. The metabolic syndrome has been defined by the National Cholesterol Education Program (NCEP) as at least three of the following: 1. Fasting blood […]

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Conditions: Abdominal obesity, Diabetes, Hyperglycemia, Hyperlipidemia, Hypertension, Hypertriglyceridemia, Insulin resistance, Metabolic syndrome

Supplements: 5-OH tryptophan, Tryptophan

Foods: Fructose

Miscellaneous: Adrenal gland, Glucocorticoids, Hypothalamic-pituitary-adrenal (HPA) axis, Neurotransmitters, Prolactin, Serotonin, SSRIs (selective serotonin re-uptake inhibitors), Uric acid (urate)

Medical Therapy of Urolithiasis.

Posted on March 7, 2007 by Dr. Gary Pack

Urolithiasis is a condition of having stones in the urinary system and it affects 5-10% of the American and European populations. Medical therapy is evolving at this time with prevention of stones including the following: 1. Drink two liters of water per day. 2. Reduce animal protein intake. 3. Reduce salt intake. 4. Consume a […]

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Conditions: Hyperuricemia, Hypocitraturia, Urinary stones (urolithiasis)

Supplements: Calcium, Chondroitin sulfate, Citric acid (citrate), Cystine, Glycosaminoglycans, Hyaluronic acid, Magnesium, Stone breaker (Phyllanthus niruri)