Hypouricemic Agent: Mulberry Twig

Posted on December 15, 2006 by Dr. Gary Pack

Hyperuricemia is associated with gout and other diseases. The incidence of gout has doubled in the past 20 years and 80 to 90% of patients with gout do not excrete uric acid normally. Lowering of the uric acid can be accomplished by xanthine oxidase (an enzyme) inhibitors and renal ureate reabsorption blockers. Allopurinal is the […]

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Conditions: Bone marrow suppression, Gastrointestinal irritation, Gout, Hyperuricemia, Skin rash

Supplements: Antioxidants, Astragalus (Astragalus membranaceus), Bioflavonoids, Morin, White mulberry (Morus alba)

Foods: Black tea (Camellia sinensis), Cocoa, Figs

Miscellaneous: Allopurinal, Traditional Chinese Medicine, Uric acid (urate), Xanthine oxidase, Xanthine oxidase inhibitors

Environmental Lead Exposure and Urate Excretion.

Posted on December 7, 2006 by Dr. Gary Pack

There is an increased incidence of gout in lead workers. Chronic lead exposure reduces urate removal by the kidneys. High uric acid is a predictor of gout. Monosodium urate crystals are found in the joint fluid of patients with gout. Over 100 healthy subjects were tested in this study. Blood lead levels were measured and […]

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Conditions: Environmental pollution, Gout, Hyperuricemia, Lead toxicity (plumbism)

Supplements: Arginine, Chelation therapy, Chelator, Plumbum metallicum homeopathic, Stone breaker (Phyllanthus niruri)

Foods: Alcohol, Anchovies, Beef kidneys, Beer, Brains, Game meats, Herring, Liver, Mackerel, Meat extracts, Sardines, Scallops, Sweetbreads

Miscellaneous: Nitric oxide (NO), Uric acid (urate)

Hyperuricemia Induces Endothelial Dysfunction.

Posted on December 7, 2006 by Dr. Gary Pack

In humans an enzyme called uricase has mutated, resulting in higher uric acid levels. Hyperuricemia is connected to cardiovascular and kidney disease. This could be the result of reactive oxygen species (ROS) causing damage to the inner endothelial lining of blood vessels. The effect of the enzyme xanthine oxidase is the production of uric acid […]

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Uric Acid in Fructose-Induced Metabolic Syndrome.

Posted on December 7, 2006 by Dr. Gary Pack

The metabolic syndrome is the cause of a worldwide epidemic consisting of: Obesity, poor tolerance to glucose, hyperinsulinemia, hyperuricemia (high serum uric acid,) hypertriglyceridemia, and hypertension, which are all risk factors for cardiovascular disease. The metabolic syndrome is seen in 27% of the population of the United States and the diagnosis of metabolic syndrome triples […]

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Xanthine Oxidase and Idiopathic Pulmonary Arterial Hypertension.

Posted on October 15, 2006 by Dr. Gary Pack

Idiopathic pulmonary arterial hypertension (IPAH) is believed to be made worse by oxidative stress. The enzyme, xanthine oxidase, contributes to that oxidative stress, causing damage to arteries by increasing uric acid levels. High uric acid levels (hyperuricemia) in IPAH are believed to be the result of increased xanthine oxidase activity. The xanthine oxidase enzyme is […]

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