Gastroesophageal Reflux Disease Treatment.

Posted on March 16, 2009 by Dr. Gary Pack

Gastroesophageal reflux disease (GERD) is becoming more common. The symptoms include heartburn, return of stomach contents up the esophagus, trouble swallowing, coughing, hoarseness and/or chest pain. With GERD, gastric contents, including stomach acid (hydrochloric acid,) are forced up into the esophagus. The most common GERD treatment at this time is with proton pump inhibitors (PPI) […]

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Conditions: Carcinogenesis, Gastroesophageal reflux

Supplements: Betaine (trimethylglycine) (TMG), Melatonin, Methionine, Tryptophan, Vitamin B-12, Vitamin B-6 (pyridoxine)

Miscellaneous: Anti-inflammatory, Nitric oxide (NO), Proton pump inhibitors

Oral L-Glutamine Increases GABA Levels.

Posted on April 10, 2008 by Dr. Gary Pack

Adequate levels of two neurotransmitters, gamma-aminobutyric acid (GABA) and glutamate, are dependent on an adequate supply of glutamine to the central nervous system (brain and spinal cord). Glutamate does not cross the blood-brain barrier, but glutamine does. Glutamine treatment increases plasma and brain levels of glutamine, and serves as raw material for the production of […]

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Conditions: Ammonia toxicity, Anxiety, Confusion, Hepatic encephalopathy, Liver failure, Schizophrenia, Seizures

Supplements: Gamma amino butyric acid (GABA), Glutamine, Tryptophan, Tyrosine

Miscellaneous: Blood-brain barrier, Catecholamines, Glutamate, Neurotransmitters, Serotonin

The Metabolic Syndrome and Serotonin Activity.

Posted on May 28, 2007 by Dr. Gary Pack

The complete cause of the metabolic syndrome is not known at the present time. The metabolic syndrome is demonstrated by abdominal obesity, altered glucose metabolism, abnormal lipid metabolism and high blood pressure. The metabolic syndrome has been defined by the National Cholesterol Education Program (NCEP) as at least three of the following: 1. Fasting blood […]

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Conditions: Abdominal obesity, Diabetes, Hyperglycemia, Hyperlipidemia, Hypertension, Hypertriglyceridemia, Insulin resistance, Metabolic syndrome

Supplements: 5-OH tryptophan, Tryptophan

Foods: Fructose

Miscellaneous: Adrenal gland, Glucocorticoids, Hypothalamic-pituitary-adrenal (HPA) axis, Neurotransmitters, Prolactin, Serotonin, SSRIs (selective serotonin re-uptake inhibitors), Uric acid (urate)

Prevention of Fetal Rejection by Tryptophan Catabolism.

Posted on March 28, 2007 by Dr. Gary Pack

The maternal immune system would, logically, reject the fetal tissue since it would be identified as foreign protein. This process is actively blocked by the fetal tissues by producing enzymes which rapidly uses up tryptophan. Systemic tryptophan levels falls during pregnancy. CONCLUSION: This article demonstrates the importance of the amino acid tryptophan, in prevention of […]

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Conditions: Autoimmune disease, Cancer, Depression, Fetal rejection, Immune depression, Niacin deficiency (pellagra), Pellagra (niacin deficiency), Pregnancy, Tryptophan deficiency

Supplements: Niacinamide, Tryptophan, Vitamin B-3 (niacin) (nicotinic acid)

Miscellaneous: Fetus, IDO (Indoleamine 2,3-dioxygenase), Immune system, Placenta

5-HT4 Receptor, Estrogen and Prolactin Release.

Posted on February 15, 2007 by Dr. Gary Pack

Serotonin (5-HT) is a neurotransmitter and neuromodulator in both the central and peripheral nervous systems. 5-HT, a hormone with widespread functions, is produced from tryptophan and works in the sensory-motor, autonomic and peripheral nervous systems. It signals cells through a large family of cell receptors (5-HTRs), and helps control the release of prolactin (PRL) at […]

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Conditions: Cancer

Supplements: 5-OH tryptophan, Tryptophan

Miscellaneous: ACTH (growth hormone), Brain stem, Central nervous system, Estradiol, Estrogen, Hypothalamus, Neurotransmitters, Peripheral nervous system, Prolactin, Serotonin, Thyroid hormone

Serotonin Dysfunction in Pathological Gamblers.

Posted on February 15, 2007 by Dr. Gary Pack

Serotonin (5-hydroxytryptamine or 5-HT) agonists mimic and enhance the effect of 5-HT. A 5-HT agonist produces a “high” and a craving response in some people with impulse disorders and some substance abuse disorders. The present study was done to evaluate 5-HT metabolism in gamblers. After a dose of a 5-HT agonist, the subjects were tested […]

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Conditions: Cancer, Hyperprolactinemia, Impulse disorders, Parkinson's disease, Pathologic gambler, Substance abuse

Supplements: 5-OH tryptophan, Boswellia (Boswellia serrata), Chasteberry (Vitex agnus castus), Tryptophan, Tyrosine

Miscellaneous: 5-lipoxygenase inhibitors, Dopamine agonists, Serotonin agonists

Premenstrual Syndrome: From Etiology to Treatment.

Posted on January 13, 2007 by Dr. Gary Pack

Physical symptoms during the premenstrual period are referred to as premenstrual syndrome (PMS) and mental symptoms in the premenstrual period are referred to as premenstrual dysphoric disorder (PMDD). The symptoms alter the person’s daily activities. The American College of Obstretics and Gynecology says that the diagnosis of PMS is made “if at least one mental […]

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Iron, Folate and Vit. B-12 in Multiple Sclerosis.

Posted on October 5, 2006 by Dr. Gary Pack

Some patients with multiple sclerosis (MS) test low for iron and benefit from iron supplementation. The present study was done on MS patients to monitor their iron, ferritin, folate and homocysteine levels and to determine if replacement of certain deficiencies altered the course of the MS. MS is considered to be an autoimmune disease in […]

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Role of Norepinephrine in Depression.

Posted on April 7, 2006 by Dr. Gary Pack

Both norepinephrine (NE) and serotonin (5-HT) play a role in depression and are involved in antidepressive pharmaceutical treatments. Studies show that NE and 5-HT interactions are involved but, neither is the “final common pathway” of depression. Neither NE nor 5-HT depletion causes depression in normal patients or in unmediated symptomatic patients with major depression. On […]

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Conditions: Depression, Sedation

Supplements: Tryptophan, Tyrosine

Miscellaneous: Amygdala, Antidepressant, Basal ganglia, Frontal cortex, Hippocampus, l-DOPA, Neuroendocrines, Norepinephrine, Serotonin

Zinc-influenced Eating Behavior.

Posted on January 22, 2006 by Dr. Gary Pack

Zinc deficiency in humans was first reported in 1963 with symptoms of dwarfism, hypogonadism and anorexia(loss of appetite). Decreased appetite is said to be the first sign of zinc deficiency. Zinc supplementation rapidly restores the intake of zinc deficient mice to normal. In one study half of all anorexia nervosa patients were found to be […]

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Conditions: Anorexia nervosa, Dwarfism, Hypogonadism, Zinc deficiency

Supplements: Tryptophan, Tyrosine, Zinc

Miscellaneous: Leptin, Norepinephrine, Serotonin

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