Arginine in Raynaud’s Phenomenon.

Posted on February 20, 2007 by Dr. Gary Pack

Raynaud’s phenomenon, whose cause is unknown, is an illness with episodes of reduced circulation to the fingers and toes. Cold temperatures cause digital artery spasms with resulting pains. The skin changes from cyanotic to white and red. At times the circulation is so impaired that there can be actual the necrosis (accidental death of cells) […]

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Conditions: Angiogenesis, Arterial spasms, Collagen disease, Necrosis, Raynaud's Phenomenon, Rheumatoid arthritis, Scleroderma

Supplements: Arginine

Miscellaneous: Nitric oxide (NO), Nitric oxide synthetase

Mega-dose Folate for Symptomatic Atherosclerosis.

Posted on January 26, 2007 by Dr. Gary Pack

Dr. Kurt Oster of Germany had a theory, thirty years ago, that xanthine oxidase (XO) enzyme was partly the cause of atherogenesis. He believed that folic acid was a XO inhibitor, mistakenly, and used folic acid to treat circulatory problems. (It was later found that a contaminant in the folic acid actually caused the XO […]

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Endothelial Dysfunction in Diabetic Erectile Dysfunction.

Posted on January 25, 2007 by Dr. Gary Pack

Erectile dysfunction (ED) is very common in diabetes mellitus. ED refers to the “inconsistent inability to achieve and maintain penile erection sufficient for adequate sexual relations.” ED is associated with diabetes, aging, high blood cholesterol (hypercholesterolemia,) hypertension, sedentary life style and cigarette smoking. ED seems to be mainly due to inability of the inner lining […]

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Omega-3 and Retinal Disease.

Posted on January 13, 2007 by Dr. Gary Pack

“Ocular neovascularization (growth of new blood vessels in the eye) is the most common cause of blindness in all age groups.” Diseases with visual loss have a first stage of loss of circulation and resulting loss of oxygen to the eye and a second stage of growth of new blood vessels (angiogenesis) resulting from the […]

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Conditions: Age-related macular degeneration, Angiogenesis, Blindness, Diabetic retinopathy, Ischemic retinopathy, Neovascularization, Retinopathy

Supplements: Arginine, Docosahexanoic acid (DHA), Eicosapentanoic acid (EPA), Milk thistle (Silybum marianum), Omega-3 fatty (linolenic) acid, Omega-6 fatty (linoleic) acid

Foods: Mother's milk

Miscellaneous: Arachidonic acid

Environmental Lead Exposure and Urate Excretion.

Posted on December 7, 2006 by Dr. Gary Pack

There is an increased incidence of gout in lead workers. Chronic lead exposure reduces urate removal by the kidneys. High uric acid is a predictor of gout. Monosodium urate crystals are found in the joint fluid of patients with gout. Over 100 healthy subjects were tested in this study. Blood lead levels were measured and […]

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Conditions: Environmental pollution, Gout, Hyperuricemia, Lead toxicity (plumbism)

Supplements: Arginine, Chelation therapy, Chelator, Plumbum metallicum homeopathic, Stone breaker (Phyllanthus niruri)

Foods: Alcohol, Anchovies, Beef kidneys, Beer, Brains, Game meats, Herring, Liver, Mackerel, Meat extracts, Sardines, Scallops, Sweetbreads

Miscellaneous: Nitric oxide (NO), Uric acid (urate)

Hyperuricemia Induces Endothelial Dysfunction.

Posted on December 7, 2006 by Dr. Gary Pack

In humans an enzyme called uricase has mutated, resulting in higher uric acid levels. Hyperuricemia is connected to cardiovascular and kidney disease. This could be the result of reactive oxygen species (ROS) causing damage to the inner endothelial lining of blood vessels. The effect of the enzyme xanthine oxidase is the production of uric acid […]

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Xanthine Oxidase and Idiopathic Pulmonary Arterial Hypertension.

Posted on October 15, 2006 by Dr. Gary Pack

Idiopathic pulmonary arterial hypertension (IPAH) is believed to be made worse by oxidative stress. The enzyme, xanthine oxidase, contributes to that oxidative stress, causing damage to arteries by increasing uric acid levels. High uric acid levels (hyperuricemia) in IPAH are believed to be the result of increased xanthine oxidase activity. The xanthine oxidase enzyme is […]

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Peripheral Neuropathy and Neuropathic Pain.

Posted on October 3, 2006 by Dr. Gary Pack

Peripheral neuropathy is most commonly caused by diabetes mellitus and neuropathy doubles the risk of amputation in diabetics. Evening primrose oil is a source of gamma-linolenic acid (GLA.), which leads to more eicosanoids that dilate blood vessels in the diabetic. Eicosanoids also cause an improvement of nerve function as evidenced by improved nerve conduction testing. […]

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Growth Hormone (GH) and the Immune System.

Posted on September 28, 2006 by Dr. Gary Pack

The pituitary gland and lymph organs, such as spleen, thymus, and peripheral blood, produce Growth hormone (GH). GH receptors are found on the surface of some lymphocytes. Previous studies have shown that GH has a function in the regulation of immunity and has been shown to have the following functions: T and B cell growth. […]

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Conditions: Immune depression

Supplements: Amino acids, Arginine, Glutamine, Growth hormone stimulators

Miscellaneous: B cell lymphocytes, Immunoglobulins, Lymph, Pituitary gland, Spleen, Stem cells (progenitor), T cell lymphocytes, Thymus gland

African Americans, Immunonutrients and Transplant Rejection Rates.

Posted on July 13, 2006 by Dr. Gary Pack

African Americans have a higher rate of rejection of kidney transplants than do Caucasians. The goal of this study was to determine if the use of micronutrients that improve immunity can reduce the rates of renal transplant rejections in African Americans. This study was done on a limited number of patients and should be viewed […]

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Conditions: Kidney transplant, Transplant rejection

Supplements: Arginine, Coromega, Docosahexanoic acid (DHA), Eicosapentanoic acid (EPA), Micronutrients, Omega-3 fatty (linolenic) acid

Miscellaneous: African Americans, Immunonutrients

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